Dermasol 0.05% (Ointment)
20 gm tube: ৳ 75.50
Medicine Details
Category | Details |
---|---|
Generic | Clobetasol propionate |
Company | Square pharmaceuticals plc |
Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Pharmacology
- Very potent topical corticosteroid
- Anti-inflammatory, antipruritic and vasoconstrictive properties
- Inhibits late phase allergic reactions
- Reduces cytokine production
- Inhibits the metabolism of arachidonic acid
Dosage
- For adults, elderly and children over 1 year
- Super-high potency topical corticosteroids
- Maximum weekly dose should not exceed 50 gm/week
- Total dose applied should not exceed 50 ml weekly (spray)
- Treatment should be limited to 2 consecutive weeks
Administration
- Route of administration: Cutaneous
- Creams are especially appropriate for moist or weeping surfaces
- Ointments are especially appropriate for dry, lichenified or scaly lesions
Interaction
- Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids
Contraindications
- Rosacea, acne vulgaris and perioral dermatitis
- Hypersensitivity to the preparation
- Not indicated for primarily infected skin lesions caused by infection with fungi or bacteria
- Not indicated for dermatoses in children under one year of age
Side Effects
- Prolonged use of large amounts can result in systemic absorption
- Local atrophic changes in the skin
- Reports of pigmentation changes and hypertrichosis
- Exacerbation of symptoms may occur
Pregnancy & Lactation
- Limited data from the use in pregnant women
- Topical administration to pregnant animals can cause abnormalities of fetal development
Precautions & Warnings
- Long-term continuous therapy should be avoided, particularly in infants and children
- Atrophic changes may occur after prolonged treatment with potent topical corticosteroids
- Care is needed to ensure the preparation does not enter the eye
Use in Special Populations
- In infants and children under 12 years of age, long-term continuous therapy should be avoided
Overdose Effects
- Acute overdosage is very unlikely to occur
Therapeutic Class
Other Topical corticosteroids
Storage Conditions
Keep below 30°C temperature, protected from light and moisture. Do not freeze