Dermasol 0.05% (Ointment)

20 gm tube: ৳ 75.50

Medicine Details

Indications

  • Psoriasis (excluding widespread plaque psoriasis)
  • Recalcitrant dermatoses
  • Lichen planus
  • Discoid lupus erythematosus
  • Other skin conditions which do not respond satisfactorily to less potent steroids

Composition

  • Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)

Pharmacology

  • Very potent topical corticosteroid
  • Anti-inflammatory, antipruritic and vasoconstrictive properties
  • Inhibits late phase allergic reactions
  • Reduces cytokine production
  • Inhibits the metabolism of arachidonic acid

Dosage

  • For adults, elderly and children over 1 year
  • Super-high potency topical corticosteroids
  • Maximum weekly dose should not exceed 50 gm/week
  • Total dose applied should not exceed 50 ml weekly (spray)
  • Treatment should be limited to 2 consecutive weeks

Administration

  • Route of administration: Cutaneous
  • Creams are especially appropriate for moist or weeping surfaces
  • Ointments are especially appropriate for dry, lichenified or scaly lesions

Interaction

  • Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids

Contraindications

  • Rosacea, acne vulgaris and perioral dermatitis
  • Hypersensitivity to the preparation
  • Not indicated for primarily infected skin lesions caused by infection with fungi or bacteria
  • Not indicated for dermatoses in children under one year of age

Side Effects

  • Prolonged use of large amounts can result in systemic absorption
  • Local atrophic changes in the skin
  • Reports of pigmentation changes and hypertrichosis
  • Exacerbation of symptoms may occur

Pregnancy & Lactation

  • Limited data from the use in pregnant women
  • Topical administration to pregnant animals can cause abnormalities of fetal development

Precautions & Warnings

  • Long-term continuous therapy should be avoided, particularly in infants and children
  • Atrophic changes may occur after prolonged treatment with potent topical corticosteroids
  • Care is needed to ensure the preparation does not enter the eye

Use in Special Populations

  • In infants and children under 12 years of age, long-term continuous therapy should be avoided

Overdose Effects

  • Acute overdosage is very unlikely to occur

Therapeutic Class

Other Topical corticosteroids

Storage Conditions

Keep below 30°C temperature, protected from light and moisture. Do not freeze

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