Dermex 0.05% (Ointment)
20 gm tube: ৳ 75.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream: 0.5 mg (0.05% w/w)
- Clobetasol Propionate Ointment: 0.5 mg (0.05% w/w)
- Clobetasol Propionate Scalp Application: 0.5 mg (0.05% w/w)
- Clobetasol Propionate Shampoo: 0.5 mg (0.05% w/w)
- Clobetasol Propionate Lotion: 0.5 mg (0.05% w/w)
- Clobetasol Propionate Spray: 0.5 mg (0.05% w/w)
Pharmacology
- Very potent topical corticosteroid
- Anti-inflammatory
- Antipruritic
- Vasoconstrictive
- Inhibition of late phase allergic reactions
- Decreased mast cell density
- Inhibition of cytokine production
Dosage
- Application of a thin layer to affected skin areas
- Twice daily application for adults, elderly, and children over 1 year
- Super-high potency topical corticosteroid
- Limited treatment period to 2 consecutive weeks
Administration
Route of administration: Cutaneous. Creams for moist or weeping surfaces. Ointments for dry, lichenified or scaly lesions.
Interaction
CYP3A4 inhibiting co-administered drugs increase systemic exposure
Contraindications
- Rosacea, acne vulgaris and perioral dermatitis
- Primary cutaneous viral infections
- Hypersensitivity to the preparation
- Children under one year of age
Side Effects
- Systemic absorption with prolonged use
- Local atrophic changes
- Possible provocation of pustular form of psoriasis
- Reports of pigmentation changes and hypertrichosis
- Signs of hypersensitivity may occur
Pregnancy & Lactation
Limited data in pregnant women. Caution during lactation.
Precautions & Warnings
- Avoid long-term continuous therapy, particularly in infants and children
- Atrophic changes may occur on the face
- Care needed when applied to the eyelids
- Hazardous in psoriasis for several reasons
- Caution with anti-microbial therapy
Use in Special Populations
Caution in infants and children under 12 years
Overdose Effects
Acute overdosage is unlikely. Chronic over-dosage may lead to hypercortisolism features.
Therapeutic Class
Other Topical corticosteroids
Storage Conditions
Keep below 30°C, protected from light and moisture, do not freeze