Dersole 0.05% (Cream)
10 gm tube: ৳ 45.13
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Sharif pharmaceuticals ltd |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
- Adults
- Elderly
- Children over 1 year old
Composition
- Clobetasol Propionate Cream
- Clobetasol Propionate Ointment
- Clobetasol Propionate Scalp Application
- Clobetasol Propionate Shampoo
- Clobetasol Propionate Lotion
- Clobetasol Propionate Spray
- Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Pharmacology
- Anti-inflammatory
- Antipruritic
- Vasoconstrictive
- Inhibits late phase allergic reactions
- Decreases mast cell density
- Inhibits cytokine production
Dosage
- Cream, Ointment
- Spray
- Shampoo
- Scalp Solution
- Cutaneous administration
- Limited to 2 consecutive weeks
- Maximum weekly dose of 50 gm/week
- Limited courses for children
- Not recommended for under 18 years
- Route of administration
Administration
- Appropriate for moist or weeping surfaces
- Appropriate for dry, lichenified or scaly lesions
Interaction
- Inhibition of CYP3A4 metabolism
Contraindications
- Rosacea
- Acne vulgaris
- Perioral dermatitis
- Primary cutaneous viral infections (e.g. herpes simplex, chickenpox)
- Hypersensitivity to the preparation
- Not indicated in fungal or bacterial infections
- Dermatoses in children under one year of age
Side Effects
- Systemic absorption
- Hypercorticism
- Local atrophy
- Pustular psoriasis
- Pigmentation changes
- Hypertrichosis
- Hypersensitivity
Pregnancy & Lactation
- Limited data in pregnant women
- Topical administration can cause abnormalities of fetal development
- Unknown excretion in human milk
- Caution for nursing women
Precautions & Warnings
- Avoid long-term continuous therapy
- Avoid in infants and children for long-term use
- Potential atrophic changes on the face
- Avoid eye contact
- Hazardous in psoriasis
- Appropriate antimicrobial therapy
Use in Special Populations
- Infants
- Children under 12 years
- Adrenal suppression
Overdose Effects
- Unlikely acute overdosage
- Features of hypercortisolism
Therapeutic Class
- Other Topical corticosteroids
Storage Conditions
- Keep below 30°C
- Protected from light and moisture
- Do not freeze
- Keep out of the reach of children