Dersole 0.05% (Ointment)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Sharif pharmaceuticals ltd |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Pharmacology
Clobetasol Propionate is a very potent topical corticosteroid. It has anti-inflammatory, antipruritic and vasoconstrictive properties. It inhibits late phase allergic reactions, mast cell density, chemotaxis, and activation of eosinophils. It also reduces cytokine production and inhibits the metabolism of arachidonic acid
Dosage
- Cream, Ointment: Apply a thin layer of Clobetasol Propionate Cream or Ointment to the affected skin areas twice daily and rub in gently and completely.
- Spray: Apply required quantity of spray once or twice daily to the affected areas of the scalp and gently rub in.
- Shampoo: Apply to the dry (not wet) scalp once a day to the affected areas only. It should be massaged gently into the lesions and left in place for 15 minutes before lathering and rinsing.
- Scalp Solution: Apply required quantity of Clobetasol Scalp Solution once or twice daily to the affected areas of the scalp and gently rub in.
Administration
Route of administration: Cutaneous. Creams are especially appropriate for moist or weeping surfaces. Ointments are especially appropriate for dry, lichenified or scaly lesions
Interaction
Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids leading to increased systemic exposure
Contraindications
- Rosacea, acne vulgaris and perioral dermatitis
- Primary cutaneous viral infections
- Hypersensitivity to the preparation
- The use of Clobetasol Propionate skin preparations is not indicated in the treatment of primarily infected skin lesions caused by infection with fungi or bacteria
- Dermatoses in children under one year of age
Side Effects
- Prolonged use of large amounts can result in systemic absorption
- Prolonged and intensive treatment may cause local atrophic changes in the skin
- In rare instances, treatment of psoriasis with corticosteroids is thought to have provoked the pustular form of the disease
- Reports of pigmentation changes and hypertrichosis with topical steroids
Pregnancy & Lactation
Limited data from the use of Clobetasol Propionate cream in pregnant women. Topical administration of corticosteroids to pregnant animals can cause abnormalities of foetal development. The relevance of this finding to humans has not been established
Precautions & Warnings
- Long-term continuous topical therapy should be avoided where possible, particularly in infants and children
- The face may exhibit atrophic changes after prolonged treatment with potent topical corticosteroids
- If applied to the eye lids, care is needed to ensure that the preparation does not enter the eye
- Topical corticosteroids may be hazardous in psoriasis for a number of reasons including rebound relapses, development of tolerance, risk of generalised pustular psoriasis
Use in Special Populations
In infants and children under 12 years of age, long-term continuous topical corticosteroid therapy should be avoided
Overdose Effects
Acute overdosage is very unlikely to occur, however, in the case of chronic over-dosage or misuse the features of hypercortisolism may occur
Therapeutic Class
Other Topical corticosteroids
Storage Conditions
Keep below 30°C temperature, protected from light and moisture. Do not freeze. Keep out of the reach of children