Nyclobate 0.05% (Cream)

10 gm tube: ৳ 45.00

Medicine Details

Category Details
Generic Clobetasol propionate
Company Incepta pharmaceuticals ltd
Also available as
Nyclobate 005 ointment Nyclobate 005 scalp solution Nyclobate 005 shampoo Nyclobate 005 spray Nyclobate 005 lotion

Indications

  • Psoriasis (excluding widespread plaque psoriasis)
  • Recalcitrant dermatoses
  • Lichen planus
  • Discoid lupus erythematosus
  • Other skin conditions which do not respond satisfactorily to less potent steroids

Composition

  • Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)

Pharmacology

  • Potent topical corticosteroid
  • Anti-inflammatory
  • Antipruritic
  • Vasoconstrictive properties
  • Inhibits late phase allergic reactions
  • Decreases mast cell density
  • Reduces cytokine production

Dosage

  • Apply a thin layer of Clobetasol Propionate Cream or Ointment to the affected skin areas twice daily
  • Super-high potency topical corticosteroids
  • Maximum weekly dose should not exceed 50 gm/week
  • Total dosage of shampoo should not exceed 50 g per week
  • Therapy should be discontinued if no response is noted after one week

Administration

  • Route of administration: Cutaneous
  • Creams are especially appropriate for moist or weeping surfaces
  • Ointments are especially appropriate for dry, lichenified or scaly lesions

Interaction

  • Co-administered drugs that can inhibit CYP3A4 can inhibit the metabolism of corticosteroids and lead to increased systemic exposure

Contraindications

  • Rosacea, acne vulgaris and perioral dermatitis
  • Hypersensitivity to the preparation
  • Not indicated in the treatment of primarily infected skin lesions caused by infection with fungi or bacteria
  • Dermatoses in children under one year of age

Side Effects

  • Prolonged use of large amounts can result in systemic absorption
  • Local atrophic changes in the skin
  • Exacerbation of symptoms may occur

Pregnancy & Lactation

  • Limited data from the use of Clobetasol Propionate cream in pregnant women
  • Caution should be exercised when administered to a nursing woman

Precautions & Warnings

  • Long-term continuous topical therapy should be avoided, particularly in infants and children
  • Care needed to ensure that the preparation does not enter the eye
  • Topical corticosteroids may be hazardous in psoriasis
  • Appropriate anti-microbial therapy should be used whenever treating inflammatory lesions

Use in Special Populations

  • Long-term continuous topical corticosteroid therapy should be avoided in infants and children under 12 years of age

Overdose Effects

  • Acute overdosage is very unlikely to occur
  • Chronic over-dosage may cause hypercortisolism

Therapeutic Class

  • Other Topical corticosteroids

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light and moisture
  • Do not freeze
  • Keep out of the reach of children

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