Nyclobate 0.05% (Ointment)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Pharmacology
Very potent topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties
Dosage
- Cream, Ointment: Apply a thin layer twice daily and rub in gently
- Spray: Apply once or twice daily to affected areas of the scalp
- Shampoo: Apply to dry scalp once a day to the affected areas only
- Scalp Solution: Apply once or twice daily to the affected areas of the scalp and gently rub in
Administration
Route of administration: Cutaneous. Creams are especially appropriate for moist or weeping surfaces. Ointments are especially appropriate for dry, lichenified, or scaly lesions
Interaction
Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids
Contraindications
- Rosacea, acne vulgaris, and perioral dermatitis
- Hypersensitivity to the preparation
- Clobetasol Propionate skin preparations is not indicated in the treatment of primarily infected skin lesions caused by infection
- Dermatoses in children under one year of age
Side Effects
- Prolonged use of large amounts can result in systemic absorption
- Local atrophic changes in the skin such as thinning, striae, and dilatation of superficial blood vessels
Pregnancy & Lactation
Limited data from the use of Clobetasol Propionate cream in pregnant women, caution should be exercised when administered to a nursing woman
Precautions & Warnings
Long-term continuous therapy should be avoided where possible, particularly in infants and children
Use in Special Populations
Long-term continuous therapy should be avoided in infants and children under 12 years of age
Overdose Effects
Acute overdosage is unlikely, but chronic over-dosage may lead to features of hypercortisolism
Therapeutic Class
Other Topical corticosteroids
Storage Conditions
Keep below 30°C, protected from light and moisture, do not freeze, keep out of the reach of children