Zapitor 20 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Apex pharmaceuticals ltd |
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Indications
- Adjunct to diet to reduce total cholesterol, LDL cholesterol, apolipoprotein B
- Reduce elevated triglycerides levels in patients with hyperlipidemia
Pharmacology
- Selective inhibitor of HMG-CoA reductase
- Lowers plasma cholesterol and lipoprotein levels
- Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL
Dosage & Administration
- Adults: Usually 10 mg once daily, may be increased to max. 80 mg once daily
- Children (10-18 years): Initially 10 mg once daily, increased to max. 20 mg once daily
Interaction
- Increased risk of myopathy with concurrent administration of cyclosporine, fibric acid derivatives, niacin, erythromycin, azole antifungals
Contraindications
- Hypersensitivity to any component
- Active liver disease
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Side Effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy & Lactation
- Contraindicated during pregnancy
- Not recommended during breastfeeding
Precautions & Warnings
- Liver function tests should be performed before initiation of treatment and periodically thereafter
Use in Special Populations
- Plasma concentrations higher in elderly subjects than in young adults
- No influence on plasma concentrations or LDL-C reduction in renal disease
Overdose Effects
- Specific treatment not available
- Symptomatic treatment and supportive measures instituted
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C33H35FN2O5
- Chemical Structure available
Common Questions about Zapitor 20 mg Tablet
- Used to avoid heart attacks and treat conditions like Mixed Dyslipidemia and Hypertriglyceridemia
- Should be taken by mouth once daily, at the same time each day
- Used for lowering cholesterol, treat heart attacks and Primary Hypercholesterolemia
- Instructions for storage and disposal should be followed
- Can slightly affect the risk of diabetes
- Should be taken for the duration prescribed by the doctor
- Can make you feel tired and may not be prescribed to children
- Does not cause thinning of the blood
- Quick tips for usage
Absorption
Rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours
Distribution
Mean volume of distribution is approximately 381 liters; 98% bound to plasma proteins
Metabolism
Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products
Excretion
Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism; mean plasma elimination half-life is approximately 14 hours
Antacid Interaction
Plasma concentrations decreased approximately 35% when coadministered
Colestipol Interaction
Plasma concentrations decreased approximately 25% when coadministered
Digoxin Interaction
Steady-state plasma digoxin concentrations increased by approximately 20%
Erythromycin Interaction
Plasma concentrations of atorvastatin increased approximately 40%
Oral Contraceptives Interaction
Increased AUC values for norethindrone and ethinyl estradiol by approximately 30% and 20%
Warfarin Interaction
No clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment