Topiclo 0.05% (Cream)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Pharmacology
Clobetasol Propionate is a very potent topical corticosteroid. It has anti-inflammatory, antipruritic and vasoconstrictive properties.
Dosage
- Adults, elderly and children over 1 year: Apply a thin layer of Clobetasol Propionate Cream or Ointment to the affected skin areas twice daily and rub in gently and completely
- Apply required quantity of spray of once or twice daily to the affected areas of the scalp and gently rub in
Administration
Route of administration: Cutaneous. Creams are especially appropriate for moist or weeping surfaces. Ointments are especially appropriate for dry, lichenified or scaly lesions
Interaction
Co-administered drugs that can inhibit CYP3A4 (eg ritonavir, itraconazole) have been shown to inhibit the metabolism of corticosteroids leading to increased systemic exposure
Contraindications
- Rosacea, acne vulgaris and perioral dermatitis
- Hypersensitivity to the preparation
- The use of Clobetasol Propionate skin preparations is not indicated in the treatment of primarily infected skin lesions caused by infection with fungi (e.g. candidiasis, tinea), or bacteria (e.g.impetigo)
- Dermatoses in children under one year of age, including dermatitis and napkin eruptions
Side Effects
- Prolonged use of large amounts can result in hypercorticism
- Prolonged and intensive treatment with a highly active corticosteroid preparation may cause local atrophic changes in the skin
- Rare instances of treatment with corticosteroids (or its withdrawal) is thought to have provoked the pustular form of the disease
- Reports of pigmentation changes and hypertrichosis with topical steroids
Pregnancy & Lactation
Clobetasol Propionate Cream should only be considered if the expected benefit to the mother outweighs the possible risks of treatment
Precautions & Warnings
- Long-term continuous topical therapy should be avoided where possible, particularly in infants and children
- The face may exhibit atrophic changes after prolonged treatment with potent topical corticosteroids
Use in Special Populations
In infants and children under 12 years of age, long-term continuous topical corticosteroid therapy should be avoided
Overdose Effects
Acute overdosage is very unlikely to occur, however, in the case of chronic over-dosage or misuse the features of hypercortisolism may occur
Therapeutic Class
Other Topical corticosteroids
Storage Conditions
Keep below 30°C temperature, protected from light and moisture. Do not freeze