Xderm 0.05% (Cream)
10 gm tube: ৳ 45.17
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Biopharma limited |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Pharmacology
- Very potent topical corticosteroid
- Anti-inflammatory, antipruritic and vasoconstrictive properties
- Inhibition of late phase allergic reactions
- Reduction of cytokine production
Dosage
- Adults, elderly and children over 1 year
- Twice daily application for affected skin areas
- Super-high potency topical corticosteroids
- Limited to 2 consecutive weeks
- Maximum weekly dose should not exceed 50 gm/week
Administration
- Route of administration: Cutaneous
- Creams are especially appropriate for moist or weeping surfaces
- Ointments are especially appropriate for dry, lichenified or scaly lesions
Interaction
- Co-administered drugs that can inhibit CYP3A4 can inhibit the metabolism of corticosteroids
Contraindications
- Rosacea, acne vulgaris and perioral dermatitis
- Hypersensitivity to the preparation
- Not indicated in the treatment of primarily infected skin lesions caused by infection with fungi or bacteria
- Dermatoses in children under one year of age
Side Effects
- Prolonged use can result in sufficient systemic absorption to produce the features of hypercorticism
- Local atrophic changes in the skin such as thinning, striae and dilatation of the superficial blood vessels
- Exacerbation of symptoms may occur
Pregnancy & Lactation
- Limited data from the use in pregnant women
- Topical administration of corticosteroids to pregnant animals can cause abnormalities of foetal development
Precautions & Warnings
- Long-term continuous topical therapy should be avoided, particularly in infants and children
- Atrophic changes may occur after prolonged treatment with potent topical corticosteroids
Use in Special Populations
- Long-term continuous topical corticosteroid therapy should be avoided in infants and children under 12 years of age
Overdose Effects
- Acute overdosage is very unlikely to occur
- Features of hypercortisolism may occur in case of chronic over-dosage
Therapeutic Class
- Other Topical corticosteroids
Storage Conditions
- Keep below 30°C temperature
- Protected from light and moisture
- Do not freeze