Xderm 0.05% (Ointment)
10 gm tube: ৳ 50.19
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Biopharma limited |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Pharmacology
- Very potent topical corticosteroid
- Anti-inflammatory, antipruritic and vasoconstrictive properties
- Inhibits late phase allergic reactions
- Reduces mast cell density and activation of eosinophils
- Inhibits cytokine production
- Inhibits arachidonic acid metabolism
Dosage
- Adults, elderly and children over 1 year
- Twice daily application of cream or ointment
- Limited to 2 consecutive weeks
- Maximum weekly dose should not exceed 50 gm/week
- Use of spray not to exceed 50 ml weekly
Administration
- Route of administration: Cutaneous
- Creams suitable for moist or weeping surfaces
- Ointments suitable for dry, lichenified or scaly lesions
Interaction
- Co-administered drugs inhibiting CYP3A4 can increase systemic exposure
Contraindications
- Rosacea, acne vulgaris, perioral dermatitis
- Hypersensitivity to the preparation
- Not indicated for primarily infected skin lesions caused by fungi or bacteria
- Not recommended for dermatoses in children under one year of age
Side Effects
- Prolonged use can result in systemic absorption
- Local atrophic changes in the skin
- Potential to provoke pustular form of psoriasis
- Reports of pigmentation changes and hypertrichosis
Pregnancy & Lactation
- Limited data from use in pregnant women
- Possible risk to the fetus
Precautions & Warnings
- Long-term continuous therapy should be avoided, especially in infants and children
- Atrophic changes may occur on the face
- Care needed to prevent entry into the eyes
- Hazardous in psoriasis for several reasons
- Appropriate anti-microbial therapy needed for inflammatory lesions
Use in Special Populations
- Long-term continuous therapy should be avoided in infants and children
Overdose Effects
- Acute overdosage is very unlikely
- Chronic over-dosage may lead to hypercortisolism
Therapeutic Class
- Other Topical corticosteroids
Storage Conditions
- Keep below 30°C, protected from light and moisture, do not freeze, keep out of the reach of children