Xenocort 0.05% (Cream)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Orion pharma ltd |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream
- Clobetasol Propionate Ointment
- Clobetasol Propionate Scalp Application
- Clobetasol Propionate Shampoo
- Clobetasol Propionate Lotion
- Clobetasol Propionate Spray
Pharmacology
Very potent topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Shows anti-inflammatory activity via multiple mechanisms to inhibit late phase allergic reactions. Decreases mast cell density, chemotaxis, and activation of eosinophils. Reduces cytokine production and inhibits the metabolism of arachidonic acid.
Dosage
- Apply a thin layer of Clobetasol Propionate Cream or Ointment to the affected skin areas twice daily
- Repetitive short courses may be used to control exacerbations
- Super-high potency topical corticosteroids; treatment should be limited to 2 consecutive weeks
- Maximum weekly dose should not exceed 50 gm/week
- Treatment should be limited to 4 consecutive weeks for Shampoo
- Total dosage of shampoo should not exceed 50 g per week
Administration
Cutaneous. Creams are especially appropriate for moist or weeping surfaces. Ointments are especially appropriate for dry, lichenified, or scaly lesions.
Interaction
Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids leading to increased systemic exposure.
Contraindications
- Rosacea, acne vulgaris, and perioral dermatitis
- Hypersensitivity to the preparation
- Primary cutaneous viral infections (e.g. herpes simplex, chickenpox)
- The use of Clobetasol Propionate skin preparations is not indicated in the treatment of primarily infected skin lesions caused by infection with fungi (e.g. candidiasis, tinea), or bacteria (e.g. impetigo); perianal and genital pruritus
- Dermatoses in children under one year of age, including dermatitis and napkin eruptions
Side Effects
- Prolonged use of large amounts can result in systemic absorption to produce the features of hypercorticism
- Prolonged and intensive treatment may cause local atrophic changes in the skin
- Treatment of psoriasis with corticosteroids (or its withdrawal) is thought to have provoked the pustular form of the disease
- Reports of pigmentation changes and hypertrichosis with topical steroids
Pregnancy & Lactation
Limited data on use in pregnant women. Topical administration of corticosteroids to pregnant animals can cause abnormalities of fetal development. Caution should be exercised when administered to a nursing woman.
Precautions & Warnings
- Long-term continuous therapy should be avoided, particularly in infants and children
- Atrophic changes may occur after prolonged treatment, especially on the face
- Care is needed to avoid entry into the eye
- Topical corticosteroids may be hazardous in psoriasis for a number of reasons
Use in Special Populations
In infants and children under 12 years of age, long-term continuous therapy should be avoided
Overdose Effects
Acute overdosage is very unlikely to occur; chronic over-dosage may lead to features of hypercortisolism
Therapeutic Class
Other Topical corticosteroids
Storage Conditions
Keep below 30°C temperature, protected from light and moisture. Do not freeze. Keep out of the reach of children