Xenovate 0.05% (Ointment)

30 gm tube: ৳ 150.00

Medicine Details

Category Details
Generic Clobetasol propionate
Company Unimed unihealth pharmaceuticals ltd
Also available as
Xenovate 005 cream Xenovate 005 scalp solution

Indications

  • Psoriasis (excluding widespread plaque psoriasis)
  • Recalcitrant dermatoses
  • Lichen planus
  • Discoid lupus erythematosus
  • Other skin conditions which do not respond satisfactorily to less potent steroids

Composition

  • Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)

Pharmacology

  • Very potent topical corticosteroid
  • Anti-inflammatory, antipruritic and vasoconstrictive properties
  • Anti-inflammatory activity via multiple mechanisms
  • Decreases mast cell density
  • Inhibits cytokine production

Dosage

  • Super-high potency topical corticosteroids
  • Limited to 2 consecutive weeks
  • Maximum weekly dose should not exceed 50 gm/week
  • Treatment should be limited to 4 consecutive weeks for shampoo
  • Total dosage of shampoo should not exceed 50 g per week

Administration

  • Route of administration: Cutaneous
  • Creams for moist or weeping surfaces
  • Ointments for dry, lichenified or scaly lesions

Interaction

  • Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids

Contraindications

  • Rosacea, acne vulgaris and perioral dermatitis
  • Hypersensitivity to the preparation
  • Not indicated in the treatment of primarily infected skin lesions caused by fungi or bacteria
  • Dermatoses in children under one year of age

Side Effects

  • Prolonged use can result in systemic absorption
  • Local atrophic changes in the skin
  • Rare instances of provoking the pustular form of psoriasis
  • Reports of pigmentation changes and hypertrichosis

Pregnancy & Lactation

  • Limited data from the use of Clobetasol Propionate cream in pregnant women
  • Topical administration of corticosteroids to pregnant animals can cause abnormalities of foetal development

Precautions & Warnings

  • Long-term continuous therapy should be avoided particularly in infants and children
  • Adrenal suppression can occur readily even without occlusion
  • Atrophic changes after prolonged treatment with potent topical corticosteroids
  • Care needed to ensure that the preparation does not enter the eye if applied to the eyelids
  • Topical corticosteroids may be hazardous in psoriasis

Use in Special Populations

  • Long-term continuous therapy should be avoided in infants and children
  • Children are more susceptible to atrophic changes

Overdose Effects

  • Acute overdosage is very unlikely to occur
  • Features of hypercortisolism may occur in case of chronic over-dosage

Therapeutic Class

  • Other Topical corticosteroids

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light and moisture
  • Do not freeze
  • Keep out of the reach of children

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