Aclobet-N (0.5 mg+5 mg+1 Lac IU)/gm (Cream)

Indications

• Short courses treatment of recalcitrant eczemas
• Neurodermatoses
• Psoriasis (excluding widespread plaque psoriasis) where secondary bacterial infection or fungal infection is present, suspected or likely to occur
• Other inflammatory conditions which do not respond satisfactorily to less active steroids

Pharmacology

• Clobetasol Propionate as a very potent corticosteroid
• Neomycin Sulphate as an antibiotic of the aminoglycoside type
• Nystatin as an antifungal

Dosage & Administration

• Apply sparingly to the affected area once or twice daily until improvement occurs
• In very resistant lesion, especially where there is hyperkeratosis, the anti-inflammatory effect of this preparation can be enhanced (if necessary) by occluding the treatment area with polythene
• Treatment should not be continued for more than 7 days without medical supervision
• If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient's condition being reviewed

Interaction

• Neomycin Sulphate can intensify and prolong the respiratory depressant effects of neuromuscular blocking agents following significant systemic absorption
• No hazardous interactions have been reported with use of Clobetasol Propionate or Nystatin

Contraindications

• Rosacea
• Acne vulgaris
• Perioral dermatitis
• Primary cutaneous viral infection (eg-Herpes simplex, chicken pox)
• Hypersensitivity to the preparation

Side Effects

• Prolonged use of large amount or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercortisolism
• Prolonged and intensive treatment with highly active corticosteroid preparations may cause local atrophic changes in the skin such as thinning, striae, and dilatation of the superficial blood vessels
• Reports of pigmentation changes and hypertrichosis with topical steroids

Pregnancy & Lactation

• Neomycin present in the maternal blood can cross the placenta and may give rise to a theoretical risk of foetal toxicity
• The safety of Clobetasol Propionate has not been established in lactating mothers

Precautions & Warnings

• Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression can occur readily even without occlusion
• If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye, as glaucoma might result

Overdose Effects

• Acute overdosage is very unlikely to occur
• In the case of chronic overdosage or misuse, the features of hypercortisolism may appear and in this situation, topical steroids should be discontinued gradually

Therapeutic Class

• Clobetasol / Clobetasone & Combined Preparations

Storage Conditions

• Store below 25°C temperature
• Do not freeze
• Keep out of reach of children

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