Aclobet-N (0.5 mg+5 mg+1 Lac IU)/gm (Ointment)

Indications

• Short courses treatment of recalcitrant eczemas
• Neurodermatoses
• Psoriasis (excluding widespread plaque psoriasis) where secondary bacterial or fungal infection is present
• Other inflammatory conditions which do not respond satisfactorily to less active steroids

Pharmacology

• Very potent corticosteroid
• Used to treat severe inflammatory skin disorders such as eczema and psoriasis
• Neomycin Sulphate is an antibiotic of the aminoglycoside type
• Nystatin is an antifungal that kills fungi and yeasts by interfering with their cell membranes
• Mechanism of topical steroids like Clobetasol is unclear
• Main effects include anti-inflammatory activity, vasoconstriction, and decrease in collagen synthesis

Dosage & Administration

• Adults: Apply sparingly once or twice daily until improvement occurs
• Treatment should not be continued for more than 7 days without medical supervision
• Elderly: Caution should be exercised in cases where a decrease in renal function exists
• Children: Suitable for use in children (2 years and over) at the same dose as adults

Interaction

• Neomycin Sulphate can intensify and prolong the respiratory depressant effects of neuromuscular blocking agents
• Systemic exposure to Neomycin Sulphate is expected to be minimal

Contraindications

• Contraindicated in rosacea, acne vulgaris and perioral dermatitis
• Primary cutaneous viral infection (e.g., herpes simplex, chicken pox)
• Hypersensitivity to the preparation

Side Effects

• Prolonged use can result in systemic absorption and hypercortisolism
• Local atrophic changes in the skin such as thinning, striae, and dilatation of the superficial blood vessels
• Pigmentation changes and hypertrichosis with topical steroids

Pregnancy & Lactation

• Topically applied Neomycin's effect in pregnancy and lactation unknown
• Neomycin can cross the placenta and may pose a theoretical risk of fetal toxicity
• Safety of Clobetasol Propionate not established in lactating mothers

Precautions & Warnings

• Long-term continuous topical therapy should be avoided particularly in infants and children
• Care to ensure the preparation does not enter the eye if applied to the eyelids

Overdose Effects

• Acute overdosage is very unlikely to occur
• Features of hypercortisolism may appear in case of chronic overdosage or misuse

Therapeutic Class

• Clobetasol / Clobetasone & Combined Preparations

Storage Conditions

• Store below 25°C temperature
• Do not freeze
• Keep out of reach of children

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