Dermex NN (0.5 mg+5 mg+1 Lac IU)/gm (Cream)

10 gm tube: ৳ 55.21

Medicine Details

Category	Details
Generic	Clobetasol propionate neomycin sulphate nystatin
Company	Opsonin pharma ltd

Short courses treatment of recalcitrant eczemas
Neurodermatoses
Psoriasis (excluding widespread plaque psoriasis) where secondary bacterial infection or fungal infection is present, suspected or likely to occur
Other inflammatory conditions which do not respond satisfactorily to less active steroids

Clobetasol Propionate is a very potent corticosteroid
Neomycin Sulphate is an antibiotic of the aminoglycoside type
Nystatin is an antifungal that kills fungi and yeasts by interfering with their cell membranes
Mechanism of topical steroids like Clobetasol, in general, is unclear
Clobetasol Propionate has topical anti-inflammatory activity
Neomycin binds to the ribosomal 30s and 50s sub-units of susceptible bacteria and inhibits protein synthesis
Nystatin acts by binding to sterols in the cell membrane of the fungus with a resultant change in membrane permeability allowing leakage of intracellular components

Adults: Apply sparingly to the affected area once or twice daily until improvement occurs
In very resistant lesion, especially where there is hyperkeratosis, the anti-inflammatory effect of this preparation can be enhanced by occluding the treatment area with polythene
Treatment should not be continued for more than 7 days without medical supervision
Elderly: This preparation is suitable for use in elderly
Children: This preparation is suitable for use in children (2 years and over) at the same dose as adults

Neomycin Sulphate can intensify and prolong the respiratory depressant effects of neuromuscular blocking agents following significant systemic absorption
No hazardous interactions reported with use of Clobetasol Propionate or Nystatin

Prolonged use of large amount or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercortisolism
Atrophic changes in the skin such as thinning, striae, and dilatation of the superficial blood vessels
Pigmentation changes and hypertrichosis with topical steroids

Neomycin present in the maternal blood can cross the placenta and may give rise to a theoretical risk of foetal toxicity
The safety of Clobetasol Propionate has not been established in lactating mothers

Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression can occur readily even without occlusion
If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye, as glaucoma might result

Acute overdosage is very unlikely to occur
In the case of chronic overdosage or misuse, the features of hypercortisolism may appear and in this situation, topical steroids should be discontinued gradually