Cutisone 0.05% (Cream)

Indications

• Relief of inflammatory and pruritic manifestations of corticosteroid responsive eczema/dermatitis

Pharmacology

• Fluticasone propionate is a glucocorticoid with high topical anti-inflammatory potency
• Low HPA-axis suppressive activity after dermal administration
• High degree of selectivity for the glucocorticoid receptor
• Therapeutic potency related to half-life of glucocorticoid-receptor complex

Dosage & Administration

• Cream: Apply a thin layer once daily
• Ointment: Apply a thin layer twice daily

Interaction

• No information available

Contraindications

• Rosacea
• Acne vulgaris
• Perioral dermatitis
• Primary cutaneous viral infections
• Hypersensitivity to any of the ingredients
• Perianal and genital pruritus
• Not indicated in the treatment of primarily infected skin lesions caused by fungi or bacteria
• Not indicated for dermatoses in children under one year of age

Side Effects

• Local burning and pruritus
• Local atrophic changes in the skin
• Dilatation of the superficial blood vessels
• Hypertrichosis and hypopigmentation
• Secondary infection
• Allergic contact dermatitis
• Exacerbation of the signs and symptoms of the dermatoses
• Features of hypercorticism with prolonged use of large amounts
• Napkin may act as an occlusive dressing in infants

Pregnancy & Lactation

• Administration during pregnancy should be considered if benefit to the mother is greater than risk to the fetus
• Excretion into human breast milk not investigated
• Therapeutic benefits must be weighed against the potential hazards to the mother and baby when used in breastfeeding mothers

Precautions & Warnings

• Low systemic absorption but prolonged application of high doses to large areas might lead to adrenal suppression
• Children may absorb proportionally larger amounts
• Atropic changes on the face after prolonged treatment with potent topical corticosteroids
• Appropriate antimicrobial therapy should be used for infected inflammatory lesions
• Withdrawal of topical corticosteroid therapy and systemic administration of antimicrobial agents for spread of infection
• Cleansing before applying fresh dressing to avoid bacterial infection

Overdose Effects

• Acute overdosage unlikely
• Chronic overdosage or misuse may lead to hypercorticism features
• Application should be discontinued in case of overdose

Therapeutic Class

• Fluticasone & combined preparations topical

Storage Conditions

• Store below 30°C
• Do not freeze

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