Ticas 0.05% (Cream)
10 gm tube: ৳ 90.61
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluticasone propionate topical |
| Company | Square pharmaceuticals plc |
Indications
- Relief of inflammatory manifestations
- Relief of pruritic manifestations
- Treatment for corticosteroid responsive eczema
- Treatment for corticosteroid responsive dermatitis
Pharmacology
- Fluticasone propionate as glucocorticoid
- High topical anti-inflammatory potency
- Low HPA-axis suppressive activity
- Therapeutic index greater than most commonly available steroids
- High degree of selectivity for glucocorticoid receptor
- Agonist activity at human glucocorticoid receptors
- Weak affinity for progesterone receptor
- Virtually no affinity for mineralocorticoid, estrogen, or androgen receptors
- Therapeutic potency related to half-life of glucocorticoid-receptor complex
- Half-life of Fluticasone propionate glucocorticoid-receptor complex: approximately 10 hours
Dosage & Administration
- Cream application: once daily
- Ointment application: twice daily
- Thin layer application for both cream and ointment
Interaction
- No available information on interactions
Contraindications
- Contraindicated in Rosacea
- Contraindicated in Acne vulgaris
- Contraindicated in Perioral dermatitis
- Contraindicated in Primary cutaneous viral infections
- Contraindicated in Hypersensitivity to any of the ingredients
- Contraindicated in Perianal and genital pruritus
- Not indicated for treatment of primarily infected skin lesions caused by fungi or bacteria
- Not indicated for dermatoses in children under one year of age
Side Effects
- Local burning
- Pruritus
- Hypersensitivity reactions
- Local atrophic changes in the skin
- Thinning of the skin
- Striae
- Dilatation of superficial blood vessels
- Hypertrichosis
- Hypopigmentation
- Secondary infection risk
- Allergic contact dermatitis risk
- Exacerbation of signs and symptoms of dermatoses
- Features of hypercorticism with prolonged use of large amounts
- Systemic absorption risk
- More likely to occur in infants and children
- Potential occurrence with occlusive dressings
- Napkin acting as occlusive dressing in infants
Pregnancy & Lactation
- Consideration of benefits versus risks during pregnancy
- Excretion into human breast milk has not been investigated
- Low plasma levels following dermal application at recommended doses
- Weighing therapeutic benefits against potential hazards during breastfeeding
Precautions & Warnings
- Low propensity for systemic absorption
- Prolonged application to large areas may lead to adrenal suppression
- Infants and small children more susceptible to systemic toxicity
- Atrophic changes more likely on the face
- Use on severe eczema should be careful
- Appropriate antimicrobial therapy for treating inflammatory lesions
- Spread of infection requires withdrawal of corticosteroid therapy
- Encouragement of bacterial infection by occlusive dressing
- Cleansing of skin before applying fresh dressing
Overdose Effects
- Acute overdosage very unlikely
- Chronic overdosage or misuse may lead to hypercorticism
- Discontinuation of application in case of overdose
Therapeutic Class
- Fluticasone & combined preparations topical
Storage Conditions
- Store below 30°C
- Do not freeze