Acerux 250 mg/vial (IV Infusion)

250 mg vial: ৳ 400.00

Medicine Details

Category Details
Generic Acyclovir injection
Company Opsonin pharma ltd
Also available as
Acerux 500 mg injection

Title

  • Acerux IV Injection for Intravenous Infusion

Categories

  • Medicine
  • Pharmaceutical

Description

  • Antiviral medication for the treatment of Herpes simplex virus, Varicella zoster virus infections, including shingles and herpes encephalitis

Indications

  • Acute clinical manifestations of Herpes simplex virus in immunocompromised patients
  • Severe primary or non-primary genital herpes in immune competent patients
  • Varicella zoster virus infection in immunocompromised patients
  • Herpes zoster (shingles) in immune competent patients who show very severe acute local or systemic manifestations of the disease
  • Herpes simplex encephalitis

Mode of Action

  • Interferes with DNA synthesis and inhibits viral replication in Herpes simplex virus and Varicella zoster virus

Dosage

  • 5 mg/kg every 8 hours for Herpes simplex infection
  • 5 mg/kg every 8 hours for very severe Herpes zoster infection
  • 10 mg/kg every 8 hours for Varicella zoster infection
  • 10 mg/kg every 8 hours for Herpes simplex encephalitis

Administration

  • Administered for five to seven days for most infections
  • Administered for at least ten days in the treatment of Herpes simplex encephalitis
  • Reconstituted and administered by slow intravenous infusion over a one-hour period
  • Compatible with specific infusion fluids
  • No preservatives

Interaction

  • Co-administration with probenecid increases half-life and area under the concentration time curve
  • Concurrent use of diuretics in patients over 60 years increases plasma levels significantly

Contraindications

  • Hypersensitivity to Acyclovir or Valacyclovir

Side Effects

  • Lethargy, tremors, hallucinations, nausea, reversible increases in liver-related enzymes, local inflammatory reactions
  • Phlebitis, vomiting, pruritus, urticaria, rashes, increases in blood urea and creatinine

Pregnancy & Lactation

  • Category B in pregnancy
  • Use during pregnancy only if benefits to the patient outweigh potential risks to the fetus
  • Use in nursing mothers only if benefits to the mother outweigh potential risks to the baby
  • No experience of the effect on human fertility

Precautions & Warnings

  • Intended for intravenous infusion only
  • Should not be administered by mouth
  • Must be given over a period of at least one hour to avoid renal tubular damage
  • Should not be administered as a bolus injection
  • Must be accompanied by adequate hydration
  • Caution in patients with neurological abnormalities, hypoxia, renal, hepatic or electrolyte abnormalities

Use in Special Populations

  • Pediatric use: dose calculated on the basis of body surface area, modified dose for impaired renal function
  • Geriatric use: no data available, special attention to dosage reduction due to low creatinine clearance
  • Renal impairment: dosage modification based on creatinine clearance

Overdose Effects

  • Elevations of serum creatinine, blood urea nitrogen, and subsequent renal failure
  • Neurological effects including confusion, seizures, and coma
  • Adequate hydration essential to reduce possibility of crystal formation in the urine
  • Hemodialysis may be considered for management

Therapeutic Class

  • Antiviral for Herpes simplex & Varicella-zoster virus infections

Duration of Treatment

  • Recommended for five to seven days in most infections
  • Recommended for at least ten days in the treatment of Herpes simplex encephalitis

Reconstitution

  • 250 mg vial reconstituted with 10 ml of Water for Injection or Sodium Chloride Intravenous Infusion
  • 500 mg vial reconstituted with 10 ml of Water for Injection or Sodium Chloride Intravenous Infusion

Storage Conditions

  • Store at 15°C to 25°C
  • Protected from light and moisture
  • Keep out of the reach of children

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