Clindacin Plus 1.2%+0.025% (Topical Gel)

Indications

• Topical treatment of Acne vulgaris

Pharmacology

• Combination of lincosamide antibiotic Clindamycin phosphate and retinoid Tretinoin
• Clindamycin binds with the 50s ribosomal subunit of susceptible bacteria and prevents elongation of peptide chain
• Clindamycin inhibits the activity of Propionibacterium acne
• Tretinoin decreases the cohesiveness of follicular epithelial cells and increases turnover

Dosage & Administration

• Application before sleep and in the morning
• Wash face gently with mild soap and water before application
• Application of sunscreen after gel application

Interaction

• Concomitant use of potentially irritating topical products should be approached with caution
• Concomitant use of Erythromycin decreases activity of Clindamycin
• Concomitant use with neuromuscular medicine increases activity of neuromuscular medicine

Contraindications

• Hypersensitivity to Clindamycin or Tretinoin or any other component of the Gel

Side Effects

• Erythema
• Scaling
• Nasopharyngitis
• Dry skin
• Cough
• Sinusitis
• Diarrhea

Pregnancy & Lactation

• Special caution while applying to a nursing mother

Precautions & Warnings

• Avoid application to eyes, nose, ear, lips, cut, burn, and other infections
• Keep away from sunlight after application

Therapeutic Class

• Topical antibiotic & retinoid preparations

Storage Conditions

• Keep below 25°C temperature
• Keep away from light & moisture
• Keep out of the reach of children

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