Acerux 500 mg/vial (IV Infusion)
500 mg vial: ৳ 700.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Acyclovir injection |
| Company | Opsonin pharma ltd |
| Also available as |
Product Title
- Acerux IV Injection for Intravenous Infusion
Categories
- Medicine
- Antiviral
- Intravenous Infusion
Description
- Acerux IV Injection is indicated for the treatment of various herpes virus infections, including herpes simplex, varicella-zoster, and herpes zoster. It exerts its antiviral effects by interfering with DNA synthesis and inhibiting viral replication. The dosages for different infections and special populations, administration recommendations, contraindications, precautions, and storage conditions should be strictly adhered to for safe and effective use.
Indications
- Acute clinical manifestations of Herpes simplex virus in immunocompromised patients
- Severe primary or non-primary genital herpes in immune competent patients
- Varicella zoster virus infection in immunocompromised patients
- Herpes zoster (shingles) in immune competent patients who show very severe acute local or systemic manifestations of the disease
- Herpes simplex encephalitis
Pharmacology
- Acyclovir exerts its antiviral effects by interfering with DNA synthesis and inhibiting viral replication. The intracellular conversion of the drug to Acyclovir Triphosphate is essential for its antiviral activity.
Dosage
- Herpes simplex infection: For normal or immunocompromised immune status: 5 mg/kg every 8 hours
- Very severe Herpes zoster infection (shingles): For normal immune status: 5 mg/kg every 8 hours
- Varicella zoster infection: For immunocompromised immune status: 10 mg/kg every 8 hours
- Herpes simplex encephalitis: For normal or immunocompromised immune status: 10 mg/kg every 8 hours
- Each dose should be administered by slow intravenous infusion over a one-hour period.
Administration
- Acyclovir IV Injection for Intravenous Infusion should be administered for five to seven days in the treatment of most infections and for at least ten days in the treatment of Herpes simplex encephalitis. It should be injected directly into a vein over one hour by a controlled-rate infusion pump or diluted for administration by infusion. The solution should not be refrigerated.
Interaction
- Co-administration of probenecid with Acerux has been shown to increase the mean half-life and the area under the concentration time curve of Acerux. Concurrent use of diuretics in patients over 60 years of age increases plasma levels significantly.
Contraindications
- Acyclovir IV Injection is contraindicated in patients known to be hypersensitive to Acyclovir or Valacyclovir.
Side Effects
- Lethargy
- Obtundation
- Tremors
- Confusion
- Hallucinations
- Agitation
- Somnolence
- Psychosis
- Convulsions
- Coma
- Phlebitis
- Nausea
- Vomiting
- Reversible increases in liver-related enzymes
- Pruritus
- Urticaria
- Rashes
- Increases in blood urea and creatinine
- Local inflammatory reactions may occur if Acerux IV Infusion is inadvertently infused into extracellular tissues
Pregnancy & Lactation
- Pregnancy category B. It should not be used during pregnancy unless the benefits clearly outweigh the potential risks to the fetus. It should only be administered to nursing mothers if the benefits to the mother outweigh the potential risks to the baby. No experience of the effect of Acyclovir on human fertility.
Precautions & Warnings
- Acerux IV injection is intended for intravenous infusion only and should not be used through any other route. Reconstituted Acerux IV Infusion has a pH of approximately 11.0 and should not be administered by mouth. Acerux IV infusion must be given over a period of at least one hour to avoid renal tubular damage. Concomitant use of other nephrotoxic drugs, pre-existing renal disease, and dehydration increase the risk of further renal impairment by Acerux.
Use in Special Populations
- Pediatric use: The dose of Acerux IV injection in children aged 1-12 years should be calculated on the basis of body surface area. Geriatric use: No data are available on this age group, but special attention should be given to dosage reduction. In patients with renal impairment, Acerux should be administered with caution and the dosage should be modified based on the degree of impairment.
Overdose Effects
- Overdosage of intravenous Acerux has resulted in elevations of serum creatinine, blood urea nitrogen, and subsequent renal failure. Neurological effects including confusion, hallucinations, agitation, seizures, and coma have been described in association with overdose. Adequate hydration is essential to reduce the possibility of crystal formation in the urine. Hemodialysis significantly enhances the removal of Acerux from the blood.
Therapeutic Class
- Herpes simplex & Varicella-zoster virus infections
Duration of Treatment
- Acerux IV Injection for Intravenous Infusion should be administered for five to seven days in the treatment of most infections and for at least ten days in the treatment of Herpes simplex encephalitis.
Reconstitution
- Each 250 mg vial of Acerux IV Injection should be reconstituted by the addition of 10 ml of either Water for Injection or Sodium Chloride Intravenous Infusion (0.9% w/v). This provides a solution containing 25 mg Acerux per ml. Each 500 mg vial of Acerux IV Injection should be reconstituted by the addition of 10 ml of either Water for Injection or Sodium Chloride Intravenous Infusion (0.9% w/v). This provides a solution containing 50 mg Acerux per ml.
Storage Conditions
- Store at 15°C to 25°C. Protected from light and moisture.