Ferrosobin G 300 mg/5 ml (Syrup)

Indications

• Iron-deficiency anemia

Pharmacology

• Replaces iron found in haemoglobin, myoglobin, and enzymes
• Facilitates transportation of oxygen via haemoglobin

Dosage & Administration

• Adult dosage: 60 mg bid up to 60 mg 4 times daily for iron-deficiency anaemia
• Child dosage: Severe - 4-6 mg/kg/day in 3 divided doses; Mild to moderate - 3 mg/kg/day in 1-2 divided doses
• Dosage for prevention: Adult - 60 mg daily, Child - 1-2 mg/kg/day
• Best taken on an empty stomach, may be taken with meals to reduce GI discomfort

Interaction

• Concurrent administration with antacids/H2 antagonists may reduce absorption of iron
• Chloramphenicol may delay response to iron
• Iron may reduce the absorption of levodopa, methyldopa, and penicillamine when given together
• Absorption may be reduced when used with quinolones or tetracyclines
• Concurrent administration with vitamin C may increase iron absorption

Contraindications

• Haemochromatosis
• Haemolytic anemia

Side Effects

• GI symptoms e.g. stomach cramping, constipation, nausea, vomiting, dark stools, heartburn, diarrhea, teeth staining, urine discoloration

Pregnancy & Lactation

• Pregnancy Category- A. Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy

Precautions & Warnings

• Avoid in patients with peptic ulcer, enteritis, or ulcerative colitis
• Not to be used in premature infants until the vitamin E stores are replenished
• Avoid prolonged treatment (>6 months) except in patients with continuous menorrhagia or bleeding

Overdose Effects

• Overdose may lead to severe iron toxicity, especially in children

Therapeutic Class

• Oral Iron preparations

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