Gentabac 0.3% (Ophthalmic Solution)

10 ml drop: ৳ 32.03

Medicine Details

Category Details
Generic Gentamicin sulfate ophthalmic
Company Popular pharmaceuticals ltd

Indications

  • Blepharitis
  • Blepharoconjunctivitis
  • Dacryocystitis
  • Keratitis
  • Keratoconjunctivitis
  • Meibomianitis
  • Corneal ulcers
  • Otorrhea
  • External otitis
  • Suppurative otitis media
  • Postoperative otorrhea

Pharmacology

  • Actively transported across bacterial cell membrane
  • Binds to specific receptor protein on the 30S subunit of bacterial ribosomes
  • Interferes with initiation complex between mRNA and the 30S subunit
  • Inhibits protein synthesis
  • May be absorbed following topical application to the eye or ear
  • Active against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Niesseria gonorrhoea, Pseudomonus aeruginosa, and Serratia marcescens

Dosage & Administration

  • 1-2 drops instilled in affected eye up to 6 times a day
  • Severe infections may require more frequent instillation initially
  • 2-3 drops instilled in affected ear every 3-4 times a day and at night

Interaction

  • None reported so far with topical and eye/ear drops

Contraindications

  • History of sensitivity reaction to any of its components
  • May allow overgrowth of nonsusceptible organisms, including fungi

Side Effects

  • Irritation (erythema and pruritus) in patients with dermatoses
  • Itching, redness, swelling, or other signs of irritation
  • Ocular burning and irritation upon drug instillation
  • Non-specific conjunctivitis
  • Conjunctival epithelial defects
  • Conjunctival hyperemia
  • Corneal ulcer during treatment with gentamicin

Pregnancy & Lactation

  • Possibility of foetal ototoxicity when applied topically to large denuded areas of skin
  • Safety profile in pregnancy not yet established

Precautions & Warnings

  • Discontinue treatment if irritation or sensitization develops
  • Not for injection
  • Avoid subconjunctival injection or direct introduction into the anterior chamber of the eye

Therapeutic Class

  • Ophthalmic antibacterial drugs

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children
  • Do not touch the tip of the container to the eye, eyelid, or any surface to avoid contamination

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