Clovate N (0.5 mg+5 mg+1 Lac IU)/gm (Cream)

10 gm tube: ৳ 65.20

Medicine Details

Category	Details
Generic	Clobetasol propionate neomycin sulphate nystatin
Company	Aci limited
Also available as	Clovate n 05 mg ointment

Short courses treatment of recalcitrant eczemas
Neurodermatoses
Psoriasis (excluding widespread plaque psoriasis) where secondary bacterial infection or fungal infection is present, suspected or likely to occur
Other inflammatory conditions which do not respond satisfactorily to less active steroids

Clobetasol Propionate is a potent corticosteroid for severe inflammatory skin disorders
Neomycin Sulphate is an antibiotic of the aminoglycoside type used to treat bacterial infections
Nystatin is an antifungal that kills fungi and yeasts by interfering with their cell membranes
Mechanism of topical steroids like Clobetasol, in general, is unclear, but has nonspecific anti-inflammatory response and vasoconstriction effect
Neomycin binds to the ribosomal sub-units of susceptible bacteria and inhibits protein synthesis
Nystatin acts by binding to sterols in the cell membrane of the fungus leading to membrane permeability

Adults: Apply sparingly once or twice daily to the affected area until improvement occurs
In very resistant lesions, enhance anti-inflammatory effect by occluding the treatment area
Caution in elderly with decreased renal function and potential systemic absorption of Neomycin Sulphate
Children (2 years and over) can use the same dose as adults

Neomycin can intensify and prolong the respiratory depressant effects of neuromuscular blocking agents following systemic absorption
No hazardous interactions reported with Clobetasol Propionate or Nystatin

Prolonged use or treatment of extensive areas can result in systemic absorption and features of hypercortisolism
More likely to occur in infants and children, especially with occlusive dressings
Prolonged and intensive treatment may cause local atrophic changes
Reports of pigmentation changes and hypertrichosis with topical steroids

Limited information on the effect of topically applied Neomycin in pregnancy and lactation
Neomycin can cross the placenta and pose a theoretical risk of foetal toxicity
Safety of Clobetasol Propionate not established in lactating mothers

Long-term continuous topical therapy should be avoided, particularly in infants and children
Care needed to prevent entry into the eyes, as glaucoma might result
If this medication enters the eye, thoroughly wash with water