Clovate N (0.5 mg+5 mg+1 Lac IU)/gm (Ointment)

Indications

• Short courses treatment of recalcitrant eczemas
• Neurodermatoses
• Psoriasis (excluding widespread plaque psoriasis) where secondary bacterial infection or fungal infection is present
• Other inflammatory conditions which do not respond satisfactorily to less active steroids

Pharmacology

• Clobetasol Propionate is a very potent corticosteroid
• Neomycin Sulphate is an antibiotic of the aminoglycoside type
• Nystatin is an antifungal that kills fungi and yeasts by interfering with their cell membranes

Dosage & Administration

• Apply sparingly to the affected area once or twice daily until improvement occurs
• Treatment should not be continued for more than 7 days without medical supervision
• This preparation is suitable for use in elderly
• This preparation is suitable for use in children (2 years and over) at the same dose as adults

Interaction

• Neomycin Sulphate can intensify and prolong the respiratory depressant effects of neuromuscular blocking agents
• No hazardous interactions have been reported with use of Clobetasol Propionate or Nystatin

Contraindications

• Rosacea
• Acne vulgaris and perioral dermatitis
• Primary cutaneous viral infection
• Hypersensitivity to the preparation

Side Effects

• Prolonged use of large amount or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercortisolism
• Prolonged and intensive treatment with highly active corticosteroid preparations may cause local atrophic changes in the skin such as thinning, striae, and dilatation of the superficial blood vessels

Pregnancy & Lactation

• The use of the preparation is not recommended in pregnancy and lactation
• The safety of Clobetasol Propionate has not been established in lactating mothers

Precautions & Warnings

• Long-term continuous topical therapy should be avoided where possible
• If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye

Overdose Effects

• Acute overdosage is very unlikely to occur
• In the case of chronic overdosage or misuse, the features of hypercortisolism may appear and in this situation, topical steroids should be discontinued gradually

Therapeutic Class

• Clobetasol / Clobetasone & Combined Preparations

Storage Conditions

• Store below 25°C temperature
• Do not freeze
• Keep out of reach of children

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