Topiclo NN (0.5 mg+5 mg+1 Lac IU)/gm (Ointment)

15 gm tube: ৳ 65.00

Medicine Details

Category	Details
Generic	Clobetasol propionate neomycin sulphate nystatin
Company	Eskayef pharmaceuticals ltd

Short courses treatment of recalcitrant eczemas
Neurodermatoses
Psoriasis (excluding widespread plaque psoriasis) where secondary bacterial infection or fungal infection is present
Other inflammatory conditions which do not respond satisfactorily to less active steroids

Clobetasol Propionate is a very potent corticosteroid
Neomycin Sulphate is an antibiotic of the aminoglycoside type
Nystatin is an antifungal that kills fungi and yeasts by interfering with their cell membranes
Topical steroids like Clobetasol have unclear mechanism of action
Neomycin binds to the ribosomal 30s and 50s sub-units of susceptible bacteria and inhibits protein synthesis
Nystatin acts by binding to sterols in the cell membrane of the fungus with a resultant change in membrane permeability allowing leakage of intracellular components

Apply sparingly to the affected area once or twice daily until improvement occurs
Treatment should not be continued for more than 7 days without medical supervision
Caution should be exercised in cases where a decrease in renal function exists and significant systemic absorption of Neomycin Sulphate may occur

Neomycin Sulphate can intensify and prolong the respiratory depressant effects of neuromuscular blocking agents following significant systemic absorption
Systemic exposure to Neomycin Sulphate is expected to be minimal and drug interactions are unlikely to be significant
No hazardous interactions have been reported with use of Clobetasol Propionate or Nystatin

Prolonged use of large amount or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercortisolism
Prolonged and intensive treatment with highly active corticosteroid preparations may cause local atrophic changes in the skin such as thinning, striae, and dilatation of the superficial blood vessels

Neomycin present in the maternal blood can cross the placenta and may give rise to a theoretical risk of foetal toxicity
Safety of Clobetasol Propionate has not been established in lactating mothers

Long-term continuous topical therapy should be avoided where possible, particularly in infants and children
If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye
Topical steroids should be discontinued gradually in case of chronic overdosage or misuse

Acute overdosage is very unlikely to occur
In case of chronic overdosage or misuse, the features of hypercortisolism may appear