Gentabac HC 0.3%+1% (Ear Drop)
10 ml drop: ৳ 51.05
Medicine Details
| Category | Details |
|---|---|
| Generic | Gentamicin hydrocortisone acetate |
| Company | Popular pharmaceuticals ltd |
Indications
- Treatment of chronic suppurative otitis media
- Treatment of otitis externa
- Prophylactic treatment of otitis externa following trauma
- Post-operative local use in surgery to infected mastoid cavities
- Treatment of redness, itching, and swelling of the skin
Pharmacology
- Gentamicin binds to 30s and 50s ribosomal subunits of bacteria disrupting protein synthesis
- Hydrocortisone has anti-inflammatory and immunosuppressive effects
- Hydrocortisone suppresses migration of leukocytes and reverses capillary permeability
- Hydrocortisone is used for replacement therapy in adrenocortical insufficiency
Dosage
- Recommended dosage for middle ear infection
- Recommended dosage for ear canal infection
- Recommended frequency of application for redness, itching, and swelling of the skin
Administration
- Product needs to be shaken well before use
Interaction
- Additive effect with neurotoxic and nephrotoxic drugs for Gentamicin
- Potentiation of anticoagulants effect for Gentamicin
- Increased risk of hypocalcaemia with bisphosphonates for Gentamicin
- Enhanced hyperglycaemia and hypokalaemia with thiazides for Hydrocortisone
- Increased incidence of peptic ulcer with concurrent NSAIDs for Hydrocortisone
Contraindications
- Hypersensitivity to aminoglycoside
- Pregnancy
- Hepatic impairment
Side Effects
- Allergic contact dermatitis
- Transient irritation
- Burning
- Stinging
- Increased redness
- Lacrimation
Pregnancy & Lactation
- Pregnancy Category- C
- Adverse effect on fetus
- Potential benefits may warrant use in pregnant women despite potential risks
Precautions & Warnings
- Concurrent use of neuromuscular blocking agents
- Conditions predisposing to ototoxicity and nephrotoxicity
- Monitoring plasma concentrations of gentamicin in certain patient groups
- Monitoring auditory and renal functions
Therapeutic Class
- Hydrocortisone & Combined preparations
- Ophthalmic steroid - antibiotic combined preparations