Gisin-H 0.3%+1% (Ear Drop)
5 ml drop: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Gentamicin hydrocortisone acetate |
| Company | Nipa pharmaceuticals ltd |
Indications
- Treatment of chronic suppurative otitis media
- Treatment of otitis externa
- Prophylactic treatment of otitis externa following trauma
- Post-operative local use in surgery to infected mastoid cavities
- Treatment for redness, itching, and swelling of the skin
Pharmacology
- Gentamicin binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis
- Hydrocortisone used for its anti-inflammatory and immunosuppressive effects
Dosage
- Instill 2-4 drops in the affected ear three to four times a day for middle ear infection
- Instill 2-4 drops in the affected ear three to four times a day for ear canal infection
- Apply cream to the affected area of the skin two or three times per day
Administration
- Ear Drops need to shake well immediately before use
Interaction
- Additive effect with other neurotoxic and/or nephrotoxic drugs including cephalosporins, methicillin, amphotericin B, ciclosporin, cisplatin, potent diuretics
- May potentiate the effect of anticoagulants
- May antagonize the effect of neostigmine and pyridostigmine
- Increased risk of hypocalcaemia with bisphosphonates
- Increased risk of neuromuscular blockade with botulinum toxin
- Indometacin may increase the plasma concentration of gentamicin in neonates
- Thiazides may enhance hyperglycaemia and hypokalaemia caused by corticosteroids
- Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin
- Response to anticoagulants altered
- Dose of antidiabetics and antihypertensives needs to be increased
- Decreases serum cone of salicylates and antimuscarinic agents
- Ethanol may enhance gastric mucosal irritation
- Reduced efficacy with concurrent use of certain drugs
- Mutual inhibition of metabolism between ciclosporin and corticosteroids
- Enhanced effect in women taking oestrogens or oral contraceptives
Contraindications
- History of hypersensitivity to aminoglycoside
- Pregnancy
- Hepatic impairment
Side Effects
- Allergic contact dermatitis
- Transient irritation
- Burning
- Stinging
- Increased redness
- Lacrimation
Pregnancy & Lactation
- Pregnancy Category- C
- Animal reproduction studies have shown an adverse effect on the fetus
- No adequate and well-controlled studies in humans
- Potential benefits may warrant use of the drug in pregnant women despite potential risks
Precautions & Warnings
- Concurrent use of neuromuscular blocking agents
- Myasthenia gravis
- Parkinsonism
- Conditions predisposing to ototoxicity and nephrotoxicity
- Lactation
- Monitor plasma concentrations of gentamicin in patients receiving high doses or prolonged courses
- Monitor auditory and renal functions
Therapeutic Class
- Hydrocortisone & Combined preparations
- Ophthalmic steroid - antibiotic combined preparations