Roaccutane 10 mg (Capsule)
Unit Price: ৳ 97.35 (3 x 10: ৳ 2,920.56)
Strip Price: ৳ 973.52
Medicine Details
| Category | Details |
|---|---|
| Generic | Isotretinoin oral |
| Company | Roche bangladesh ltd |
| Also available as |
Indications
- Severe nodular or conglobate acne
- Acne at risk of permanent scarring
Pharmacology
- Alters cell cycle and differentiation
- Reduces sebum production
- Reduces acne causing bacteria growth
- Induces apoptosis in sebocytes
- Reduces formation of comedones
Dosage & Administration
- To be taken once or twice daily with food
- Initial dose of 0.5 mg/kg daily for adults
- Dose adjustment during therapy
- Treatment course of 16-24 weeks
- Lower initial dose for severe renal insufficiency
- Not recommended for prepubertal acne
- Continued treatment at lower dose for intolerance cases
Interaction
- Additive adverse effects with vit A or its derivatives
- Decreased efficacy with microdosed progesterone
- Increased risk of local irritation with topical keratolytic agents
- Reduced efficacy with oxidising agents like benzoyl peroxide
Contraindications
- Contraindicated in pregnant or breastfeeding women
- Contraindicated in women of childbearing potential without meeting Pregnancy Prevention Programme conditions
- Contraindicated in patients with hypersensitivity or hepatic insufficiency
- Contraindicated in patients with excessively elevated blood lipid values or hypervitaminosis A
- Contraindicated with concomitant tetracycline treatment
Side Effects
- Dose-related and reversible side effects
- Dryness of skin and mucosae
- Various blood and lymphatic system disorders
- Immune system, metabolic, and psychiatric disorders
- Nervous system, eye, ear, vascular, gastrointestinal, hepatobiliary, skin, musculo-skeletal, renal, and general disorders
- Overdose symptoms and pharmaceutical precautions
Pregnancy & Lactation
- Absolute contraindication in pregnancy
- Severe malformations and increased risk of spontaneous abortion
- Contraindicated in nursing mothers due to lipophilicity
Precautions & Warnings
- Comprehensive contraception and pregnancy testing
- Follow-up visits and prescribing restrictions for women
- Precautions for male patients and medication sharing
- Discontinuation for psychiatric disorders, skin and subcutaneous disorders, eye disorders, musculo-skeletal disorders, and others
Therapeutic Class
- Oral retinoids for Acne
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children