G-Atropine 0.6 mg/ml (Injection)

Indications

• Cardiovascular disorders
• Anaesthetic premedication
• Anticholinesterase and mushroom poisoning
• Control of muscarinic side-effects of neostigmine
• Management of bradycardia of acute myocardial infarction

Pharmacology

• Binds to and inhibit muscarinic acetylcholine receptors
• Produces anticholinergic effects
• Abolishes bradycardia
• Reduces heart block due to vagal activity
• Relaxes smooth muscles in the bronchi and gut
• Reduces glandular secretions
• Has mydriatic and cycloplegic effect

Dosage & Administration

• Initial doses in the range of 0.5 to 1.0 mg intravenously
• Suitable paediatric premedication doses based on children's weight
• Usage in anticholinesterase and mushroom poisoning with very large doses
• Infants and children are particularly susceptible to toxic effects of atropine

Interaction

• Additive with other drugs having anticholinergic activity
• May delay the onset of action of other drugs
• Addition of metoclopramide accentuates the reduction of lower oesophageal pressure produced by atropine premedication

Contraindications

• Glaucoma
• Chronic lung disease
• Unstable cardiac rhythm
• Prostatic hypertrophy
• Reflux oesophagitis
• Paralytic ileus or pyloric stenosis
• Generally in the elderly

Side Effects

• Dryness of the mouth
• Difficulty in swallowing and talking
• Thirst
• Reduced bronchial secretions
• Mydriasis with loss of accomodation
• Photophobia
• Flushing
• Dryness of skin
• Transient bradycardia followed by tachycardia with palpitations and arrhythmias
• Difficulty in micturition
• Reduction in the tone and motility of GIT leading to constipation
• Occasional vomiting

Pregnancy & Lactation

• Negligible effects on the human uterus
• Not teratogenic
• Small quantities appear in breast milk
• Reported to impair milk production

Precautions & Warnings

• Caution in children and geriatric patients
• Cautious in patients with diarrhoea or fever
• Increased susceptibility in persons with Down's syndrome
• Care required in conditions characterized by tachycardia
• May cause mental confusion, especially in the elderly
• Reduced bronchial secretion may be associated with the formation of mucous plugs

Therapeutic Class

• Anticholinergics (antimuscarinics)/ Anti-spasmodics

Storage Conditions

• Keep below 25°C temperature
• Away from light & moisture
• Keep out of the reach of children

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