Asunra 400 mg (Dispersible Tablet)
Unit Price: ৳ 187.00 (3 x 10: ৳ 5,610.00)
Strip Price: ৳ 1,870.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Deferasirox |
| Company | Novartis bangladesh ltd |
| Also available as |
Indications
- Treatment of chronic iron overload
- Chronic iron overload due to blood transfusions
- Thalassaemia treatment
- Sickle cell disease treatment
- Myelodysplastic syndrome treatment
- Non-transfusion-dependent thalassemia syndrome treatment
Pharmacology
- Orally active chelator
- Highly selective for iron
- Tridentate ligand
- Binds iron in 2:1 ratio
- Promotes excretion of iron
- Low affinity for zinc and copper
- Iron excretion study in thalassaemia patients
Dosage
- Initiation after transfusion of 20 units of packed red blood cells
- Initial daily dose of 20-40 mg/kg
- Serum ferritin monitoring every month
- Dose adjustment based on serum ferritin trends
Administration
- Once daily on empty stomach
- Tablets dispersed in water or juice
- Must not be chewed or swallowed whole
- Not to be taken with carbonated drinks or milk
Interaction
- Avoid with aluminium-containing antacids
- Caution with CYP3A4 metabolized drugs
- Consider dose increase with concomitant use of specific drugs
- Interaction with drugs with ulcerogenic potential
- Caution with anticoagulants
Contraindications
- Hypersensitivity to active substance or excipients
- Creatinine clearance less than 40 ml/min
- Serum creatinine >2 times upper limit of normal
Side Effects
- Cytopenias
- Gastrointestinal effects
- Headache and dizziness
- Elevation of hepatic transaminases
- Stevens-Johnson syndrome
- Auditory and ocular disturbances
Pregnancy & Lactation
- Pregnancy Category C
- No adequate studies in pregnant women
- Possible excretion in human milk
Precautions & Warnings
- Gastrointestinal bleeding and ulceration
- Caution with drugs having ulcerogenic potential
- Monitoring blood counts
- Serious hypersensitivity reactions
Use in Special Populations
- Pediatric use similar to adult use
- Elderly patients at increased risk
- Not studied in patients with renal or hepatic impairment
Overdose Effects
- Maximal dose of 40 mg/kg
- No information about overdose
Therapeutic Class
- Antidote preparations
Storage Conditions
- Store below 25°C
- Protect from light