Desirox 250 mg (Dispersible Tablet)

Unit Price: ৳ 50.00 (30's pack: ৳ 1,500.00)

Medicine Details

Category Details
Generic Deferasirox
Company Cipla limited
Also available as
Desirox 500 mg tablet

Indications

  • Treatment of chronic iron overload in adult and pediatric patients with thalassaemia, sickle cell disease, and myelodysplastic syndrome
  • Treatment of chronic iron overload in non-transfusion dependent thalassemia syndromes

Pharmacology

  • Orally active chelator
  • Highly selective for iron
  • Binds iron with high affinity in a 2:1 ratio
  • Promotes excretion of iron primarily in the faeces
  • Low affinity for zinc and copper
  • Does not cause constant low serum levels of zinc and copper

Dosage

  • Recommended initial daily dose of 20-40 mg/kg body weight per day
  • Empty stomach administration
  • Tablets are dispersed in water or juice
  • Monthly monitoring of serum ferritin
  • Dose adjustment every 3 to 6 months based on serum ferritin trends

Administration

  • To be taken once daily on an empty stomach at least 30 minutes before food
  • Tablets are dispersed in water or juice

Interaction

  • Should not be taken with aluminium-containing antacids
  • Caution with drugs metabolized through CYP3A4
  • Dose adjustment when combined with rifampicin, phenytoin, phenobarbital, ritonavir, etc.
  • Potential interaction with CYP2C8 substrates like paclitaxel
  • Caution with drugs with ulcerogenic potential
  • Caution with anticoagulants

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Creatinine clearance less than 40 ml/min
  • Serum creatinine greater than 2 times the upper limit of normal

Side Effects

  • Cytopenias
  • Gastrointestinal effects like diarrhea, constipation, vomiting, nausea, abdominal pain, and distension
  • Upper gastrointestinal ulceration and hemorrhage
  • Headache and dizziness
  • Elevation of hepatic transaminases
  • Rare cases of Stevens-Johnson syndrome and skin rash
  • Auditory and ocular disturbances

Pregnancy & Lactation

  • Pregnancy Category C
  • No adequate and well-controlled studies in pregnant women
  • Decreased offspring viability and increase in renal anomalies observed in animal studies
  • Use during pregnancy only if potential benefit justifies potential risk to the fetus
  • Not known whether excreted in human milk

Precautions & Warnings

  • Fatal and non-fatal gastrointestinal bleeding, ulceration, and irritation may occur
  • Cautious use in combination with drugs with ulcerogenic or hemorrhagic potential
  • Monitor blood counts during therapy
  • Report severe hypersensitivity reactions

Use in Special Populations

  • Similar safety and efficacy in pediatric patients as in adults
  • Elderly patients at increased risk for toxicity
  • Safety not studied in patients with renal impairment or hepatic impairment

Overdose Effects

  • No information available

Therapeutic Class

  • Antidote preparations

Storage Conditions

  • Store in a dry place below 25°C
  • Protect from light
  • Keep out of the reach of children

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