Difol TR 150 mg+0.5 mg (Capsule (Timed Release))

Indications

• Treatment and prophylaxis of iron and folic acid deficiency
• Special focus on pregnancy and lactation

Type

• Capsule preparation

Ingredients

• Ferrous sulfate
• Timed-release form of iron
• Folic acid

Release Mechanism

• Timed-release designed for preventing gastric side effects
• Ensures maximum absorption at the site of absorption

Pharmacological Action

• Essential for haemoglobin formation
• Necessary for oxidative processes
• Absorption from the duodenum and upper jejunum
• Difference in absorption between ferrous and ferric salt forms
• Increased requirements during pregnancy

Dosage & Administration

• 1 capsule daily throughout pregnancy and lactation
• Higher dosage for some patients based on dietary or other factors

Interaction

• Diminished absorption when taken concomitantly with tetracyclines
• Decreased absorption by magnesium trisilicate-containing antacid

Contraindications

• Patients receiving repeated blood transfusions
• Patients with anaemias not produced by iron deficiency unless iron deficiency is also present

Side Effects

• Gastrointestinal irritation
• Dose-related nausea and epigastric pain

Precautions & Warnings

• Chelates with antacid and tetracycline
• Impaired absorption if taken concurrently

Overdose Effects

• Symptoms of overdosage include epigastric pain, nausea, vomiting, haematemesis, and circulatory collapse
• Potential for severe complications like encephalopathy, acute hepatic necrosis, and acute renal failure
• Treatment with desferrioxamine
• Serum iron level monitoring

Therapeutic Class

• Iron & Vitamin Combined preparations

Storage Conditions

• Do not store above 25°C
• Keep away from light and wet places
• Keep out of reach of children

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