Virunil 250 mg/vial (IV Infusion)
250 mg vial: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Acyclovir injection |
| Company | Globe pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of acute clinical manifestations of Herpes simplex virus in immunocompromised patients
- Treatment of severe primary or non-primary genital herpes in immune competent patients
- Treatment of Varicella zoster virus infection in immunocompromised patients
- Treatment of Herpes zoster (shingles) in immune competent patients
- Treatment of Herpes simplex encephalitis
Pharmacology
- Interference with DNA synthesis
- Inhibition of viral replication
- Intracellular conversion to Acyclovir Triphosphate
- Conversion to Acyclovir Monophosphate via virus-coded thymidine kinase
- Phosphorylation to diphosphate via cellular guanylate kinase
Dosage
- Dosage for Herpes simplex infection: 5 mg/kg every 8 hours
- Dosage for severe Herpes zoster infection (shingles): 5 mg/kg every 8 hours
- Dosage for Varicella zoster infection: 10 mg/kg every 8 hours
- Dosage for Herpes simplex encephalitis: 10 mg/kg every 8 hours
- Each dose should be administered by slow intravenous infusion over a one-hour period
Administration
- Recommended duration of administration: 5 to 7 days for most infections
- Recommended duration of administration for Herpes simplex encephalitis: at least 10 days
- Injection directly into a vein over one hour by a controlled-rate infusion pump
- Dilution of infusion solution
- Compatibility with various infusion fluids
Interaction
- Co-administration with probenecid
- Effects of diuretic use in patients over 60 years
Contraindications
- Hypersensitivity to Acyclovir
- Hypersensitivity to Valacyclovir
Side Effects
- Lethargy
- Tremors
- Nausea
- Vomiting
- Reversible increases in liver-related enzymes
- Pruritus
- Urticaria
- Local inflammatory reactions
Pregnancy & Lactation
- Pregnancy category B
- Use during pregnancy only if benefits outweigh risks
- Administration to nursing mothers
Precautions & Warnings
- Intended for intravenous infusion only
- Avoid oral administration
- Infusion over a period of one hour
- Accompanied by adequate hydration
- Caution in patients with neurological abnormalities
Use in Special Populations
- Dosage calculation in children based on body surface area
- Special attention to dosage reduction in the elderly
- Administration with caution in patients with renal impairment
Overdose Effects
- Elevations of serum creatinine
- Neurological effects including confusion, seizures and coma
- Importance of adequate hydration
- Consideration of hemodialysis
Therapeutic Class
- Herpes simplex & Varicella-zoster virus infections
Duration of Treatment
- Recommended duration: 5 to 7 days for most infections
- Recommended duration for Herpes simplex encephalitis: at least 10 days
Reconstitution
- Reconstitution of 250 mg vial with Water for Injection or Sodium Chloride Intravenous Infusion
- Reconstitution of 500 mg vial with Water for Injection or Sodium Chloride Intravenous Infusion
Storage Conditions
- Storage at 15°C to 25°C
- Protection from light and moisture
- Keep out of the reach of children