Cynovit 1000 mcg/ml (IM/SC Injection)
1 ml ampoule: ৳ 6.00 (5 x 5: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Cyanocobalamin |
| Company | Chemist laboratories ltd |
Indications
- Pernicious anemia
- Vitamin B12 deficiency
- Thyrotoxicosis
- Hemorrhage
- Malignancy
- Liver or kidney disease
- Gastric bypass surgery
- Gluten enteropathy or sprue
- Folic acid deficiency
- Macrocytic anaemia
Pharmacology
- Required for normal erythropoiesis
- Nucleoprotein and myelin synthesis
- Cell reproduction
- Normal growth
- Coenzyme for metabolic functions
- Protein synthesis
- Carbohydrate metabolism
- Role in cell replication
- Hematopoiesis
Dosage & Administration
- Usual Adult Dose for Pernicious Anemia: 1000 mcg initial dose intramuscularly or deep subcutaneous once a day for 6 to 7 days
- Maintenance dose: 100 to 1000 mcg monthly
- Usual Adult Dose for B12 Nutritional Deficiency: 25 to 2000 mcg orally daily
- Usual Pediatric Dose for B12 Nutritional Deficiency: 0.5 to 3 mcg daily
Interactions
- Absorption reduced by antibiotics
- Aminosalicylic acid
- Anticonvulsants
- Biguanides
- Cholestyramine
- Cimetidine
- Colchicine
- K salts
- Methyldopa
Contraindications
- Leber's disease
- Tobacco amblyopia
Side Effects
- Arthralgia
- Dizziness
- Headache
- Nasopharyngitis
- Anaphylaxis
- Angioedema
- Congestive heart failure
- Peripheral vascular disease
- Pulmonary edema
- Diarrhea
- Dyspepsia
- Polycythemia vera
- Sore throat
- Nervousness
- Rhinitis
- Glossitis
- Hypoesthesia
Pregnancy & Lactation
- Pregnancy Category A
- No risk to the fetus in the first trimester
- Drug distributed in milk
Precautions & Warnings
- Intensive treatment may cause hypokalemia
- Use with caution in patients with Leber optic nerve atrophy
- Thrombocytosis may occur with treatment of severe vitamin B12 megaloblastic anemia
Therapeutic Class
- Vitamin-B preparations