Cynomin 250 mcg/ml (IM/SC Injection)

1 ml ampoule: ৳ 4.51 (10's pack: ৳ 45.10)

Medicine Details

Category Details
Generic Cyanocobalamin
Company Jayson pharmaceuticals ltd
Also available as
Cynomin 1000 mcg injection

Indications

  • Pernicious anemia
  • Vitamin B12 deficiency due to low intake from food
  • Thyrotoxicosis
  • Hemorrhage
  • Malignancy
  • Liver or kidney disease
  • Gastric bypass surgery
  • Total or partial gastrectomy
  • Gluten enteropathy or sprue
  • Folic acid deficiency
  • Macrocytic anaemia

Pharmacology

Vitamin B12 (cyanocobalamin) is required for the maintenance of normal erthropoiesis, nucleprotein and myelin synthesis, cell reproduction and normal growth; Coenzyme; metabolic functions include protein synthesis and carbohydrate metabolism. Plays role in cell replication and hematopoiesis.

Dosage & Administration

  • Usual Adult Dose for Pernicious Anemia:
    • 1000 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 days
    • 100 mcg every other day for 7 doses, then
    • 100 mcg every 3 to 4 days for 2 to 3 weeks, then
    • Maintenance dose: 100 to 1000 mcg monthly
  • Usual Adult Dose for B12 Nutritional Deficiency: 25 to 2000 mcg orally daily
  • Usual Adult Dose for Schilling Test: 1000 mcg intramuscularly is the flushing dose
  • Usual Pediatric Dose for B12 Nutritional Deficiency: 0.5 to 3 mcg daily

Interaction

Absorption reduced by antibiotics, aminosalicylic acid, anticonvulsants, biguanides, cholestyramine, cimetidine, colchicine, K salts, methyldopa

Contraindications

  • Leber's disease
  • Tobacco amblyopia

Side Effects

  • Arthralgia
  • Dizziness
  • Headache
  • Nasopharyngitis
  • Anaphylaxis
  • Angioedema
  • Congestive heart failure
  • Peripheral vascular disease
  • Pulmonary edema
  • Diarrhea
  • Dyspepsia
  • Polycythemia vera
  • Sore throat
  • Nervousness
  • Rhinitis
  • Glossitis
  • Hypoesthesia

Pregnancy & Lactation

  • Pregnancy Category: A
  • Lactation: Drug distributed in milk

Precautions & Warnings

Intensive treatment of B12-deficient megaloblastic anemia may cause hypokalemia and sudden death. Use with caution in patients with Leber optic nerve atrophy. Thrombocytosis may occur with treatment of severe vitamin B12 megaloblastic anemia

Therapeutic Class

Vitamin-B preparations

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