G-Vitamin B12 1000 mcg/ml (IM/SC Injection)

1 ml ampoule: ৳ 7.00 (1 x 5: ৳ 35.00)

Medicine Details

Category Details
Generic Cyanocobalamin
Company Gonoshasthaya pharma ltd

Indications

  • Pernicious anemia
  • Vitamin B12 deficiency due to low intake from food
  • Thyrotoxicosis
  • Hemorrhage
  • Malignancy
  • Liver disease
  • Kidney disease
  • Gastric bypass surgery
  • Total or partial gastrectomy
  • Gluten enteropathy or sprue
  • Folic acid deficiency
  • Macrocytic anemia

Pharmacology

Required for the maintenance of normal erthropoiesis, nucleoprotein and myelin synthesis, cell reproduction and normal growth, coenzyme, metabolic functions include protein synthesis and carbohydrate metabolism, plays a role in cell replication and hematopoiesis

Dosage & Administration

  • Usual Adult Dose for Pernicious Anemia:
    • 1000 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 days
    • 100 mcg every other day for 7 doses, then
    • 100 mcg every 3 to 4 days for 2 to 3 weeks, then
    • Maintenance dose: 100 to 1000 mcg monthly
  • Usual Adult Dose for B12 Nutritional Deficiency: 25 to 2000 mcg orally daily
  • Usual Adult Dose for Schilling Test: 1000 mcg intramuscularly is the flushing dose
  • Usual Pediatric Dose for B12 Nutritional Deficiency: 0.5 to 3 mcg daily

Interaction

Absorption reduced by antibiotics, aminosalicylic acid, anticonvulsants, biguanides, cholestyramine, cimetidine, colchicine, K salts, methyldopa

Contraindications

  • Leber's disease
  • Tobacco amblyopia

Side Effects

  • Arthralgia
  • Dizziness
  • Headache
  • Nasopharyngitis
  • Anaphylaxis
  • Angioedema
  • Congestive heart failure
  • Peripheral vascular disease
  • Pulmonary edema
  • Diarrhea
  • Dyspepsia
  • Polycythemia vera
  • Sore throat
  • Nervousness
  • Rhinitis
  • Glossitis
  • Hypoesthesia

Pregnancy & Lactation

  • Pregnancy Category: A
  • Lactation: Drug distributed in milk

Precautions & Warnings

  • Intensive treatment of B12-deficient megaloblastic anemia may cause hypokalemia and sudden death
  • Use with caution in patients with Leber optic nerve atrophy
  • Thrombocytosis may occur with treatment of severe vitamin B12 megaloblastic anemia

Therapeutic Class

Vitamin-B preparations

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