Vitamin B12 1000 mcg/ml (IM/SC Injection)
1 ml ampoule: ৳ 6.00 (5 x 5: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Cyanocobalamin |
| Company | Rephco pharmaceuticals ltd |
Indications
- Pernicious anemia
- Vitamin B12 deficiency due to low intake from food
- Thyrotoxicosis
- Hemorrhage
- Malignancy
- Liver or kidney disease
- Gastric bypass surgery
- Total or partial gastrectomy
- Gluten enteropathy or sprue
- Folic acid deficiency
- Macrocytic anemia
Pharmacology
- Maintenance of normal erythropoiesis
- Nucleoprotein and myelin synthesis
- Cell reproduction and normal growth
- Coenzyme
- Protein synthesis
- Carbohydrate metabolism
- Cell replication
- Hematopoiesis
Dosage & Administration
- Usual Adult Dose for Pernicious Anemia: 1000 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 days
- Maintenance dose: 100 to 1000 mcg monthly
- Usual Adult Dose for B12 Nutritional Deficiency: 25 to 2000 mcg orally daily
- Usual Pediatric Dose for B12 Nutritional Deficiency: 0.5 to 3 mcg daily
Interaction
- Absorption reduced by antibiotics
- Aminosalicylic acid
- Anticonvulsants
- Biguanides
- Cholestyramine
- Cimetidine
- Colchicine
- K salts
- Methyldopa
Contraindications
- Leber's disease
- Tobacco amblyopia
Side Effects
- Arthralgia
- Dizziness
- Headache
- Nasopharyngitis
- Anaphylaxis
- Angioedema
- Congestive heart failure
- Diarrhea
- Dyspepsia
- Polycythemia vera
- Sore throat
- Nervousness
- Rhinitis
- Glossitis
- Hypoesthesia
Pregnancy & Lactation
- Pregnancy Category A
- Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy
- No evidence of risk in later trimesters
- Drug distributed in milk
Precautions & Warnings
- Intensive treatment of B12-deficient megaloblastic anemia may cause hypokalemia and sudden death
- Use with caution in patients with Leber optic nerve atrophy
- Thrombocytosis may occur with treatment of severe vitamin B12 megaloblastic anemia
Therapeutic Class
- Vitamin-B preparations