MB 12 500 mcg (Tablet)

Unit Price: ৳ 4.03 (3 x 10: ৳ 120.90)

Strip Price: ৳ 40.30

Medicine Details

Category	Details
Generic	Mecobalamin
Company	Acme laboratories ltd
Also available as	Mb 12 500 mcg injection

Indications

Peripheral neuropathy
Diabetic neuropathy
Alcoholic neuropathy
Drug induced neuropathy
Entrapment neuropathy
Lumbago
Intercostal neuralgia
Diabetic retinopathy
Multiple sclerosis
Vertebral syndrome
Parkinson's disease
Alzheimar's disease
Bell's palsy
Megaloblastic anemia due to vitamin B12 deficiency

Pharmacology

Mecobalamin is a coenzyme form of vitamin B12. It is a cofactor in the enzyme methionine synthase, required for integrity of myelin, neuronal function, red blood cell formation, DNA synthesis, neuronal lipid synthesis, axonal nerves regeneration, axonal transport, and neuroprotective activity.

Dosage & Administration

Tablet: 0.5 mg tablet 3 times daily after meal. Dosage should be adjusted according to patient's age and symptom severity.
Injection:
- Peripheral Neuropathies: Adult: 1 ampoule (Mecobalamin 500 mcg) daily, administered IM or IV 3 times a week. Dose may be adjusted based on age and symptoms.
- Megaloblastic Anemia: Adult: 1 ampoule (Mecobalamin 500 mcg) daily, administered IM or IV 3 times a week. After 2 months, dose should be reduced to a single administration at 1 to 3 month intervals for maintenance therapy.
- Use in Children: Not Recommended.

Interaction

Absorption of vitamin B12 may be reduced by neomycin, aminosalicylic acid, histamine H2-antagonists, omeprazole, and colchicine. Serum concentrations may be decreased by oral contraceptives.

Contraindications

Hypersensitivity to Mecobalamin or other components of the formulation.

Side Effects

Dermatologic Effects: Rash; In the event of such symptoms, treatment should be discontinued.
Gastrointestinal Effects: Anorexia, nausea/vomiting and diarrhea.
Neurologic Effects (Central nervous system): Headache.
Others: Anaphylactoid reaction, hot sensation, diaphoresis, pain/induration at the site of intramuscular injection.

Pregnancy & Lactation

No data available for mecobalamin use in pregnant women & lactating mothers. However, vitamin B12 is usually compatible with breastfeeding.

Precautions & Warnings

MB 12 should not be used aimlessly for more than one month unless effective. Prolonged use of larger doses is not recommended for patients handling mercury or mercury compounds.