Methicol 500 mcg (Tablet)

Unit Price: ৳ 4.03 (6 x 10: ৳ 241.80)

Strip Price: ৳ 40.30

Medicine Details

Category	Details
Generic	Mecobalamin
Company	Square pharmaceuticals plc

Indications

Peripheral neuropathy
Diabetic neuropathy
Alcoholic neuropathy
Drug induced neuropathy
Entrapment neuropathy
Lumbago
Intercostal neuralgia
Diabetic retinopathy
Multiple sclerosis
Vertebral syndrome
Parkinson's disease
Alzheimer's disease
Bell's palsy
Treatment of peripheral neuropathies megaloblastic anemia due to vitamin B12 deficiency

Pharmacology

Mecobalamin is one of the two coenzyme forms of vitamin B12. It is a cofactor in the enzyme methionine synthase, required for integrity of myelin, neuronal function, red blood cell formation, DNA synthesis, synthesis of neuronal lipids, regeneration of axonal nerves, promotes axonal transport and has neuroprotective activity.

Dosage & Administration

Tablet: 0.5 mg tablet 3 times daily after meal. Dosage should be adjusted according to age and severity of symptoms.
Injection:
- For Peripheral Neuropathies in Adults: 1 ampoule (Mecobalamin 500 mcg) daily, administered IM or IV 3 times a week. Dose may be adjusted depending on age and symptoms.
- For Megaloblastic Anemia in Adults: 1 ampoule (Mecobalamin 500 mcg) daily, administered IM or IV 3 times a week. After 2 months, reduce to a single administration at 1 to 3 month intervals for maintenance therapy.
- Use in Children: Not Recommended

Interaction

Absorption of vitamin B12 from the gastrointestinal tract may be reduced by certain medications. Serum concentrations may be decreased by use of oral contraceptives. Consider these interactions when performing assays for blood concentrations.

Contraindications

Hypersensitivity to Mecobalamin or other components of the formulation.

Side Effects

Dermatologic Effects: Rash
Gastrointestinal Effects: Anorexia, nausea/vomiting, diarrhea
Neurologic Effects (Central nervous system): Headache
Others:
- Anaphylactoid reaction: decrease in blood pressure or dyspnea, may occur. Patients should be carefully observed.
- Hot sensation
- Diaphoresis
- Pain/induration at the site of intramuscular injection

Pregnancy & Lactation

There are no data available for mecobalamin to be used in pregnant women and lactating mothers. However, since vitamin B12 is distributed into breast milk, its use is usually compatible with breastfeeding according to The American Academy of Pediatrics.

Precautions & Warnings

Methicol should not be used aimlessly for more than one month unless it is effective. Prolonged use of larger doses of Methicol is not recommended for patients whose occupation requires handling of mercury or mercury compounds.