Napronex 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Apex pharmaceuticals ltd
Also available as
Napronex 500 mg tablet

Indications

  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Decrease risk of gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Prostaglandin synthesis inhibition
  • Proton pump inhibitor action

Dosage

  • Lowest effective dose
  • Twice daily dosage for different conditions
  • Dosage based on weight for adolescent patients

Administration

  • Take 30 minutes before meals

Interaction

  • Reduced antihypertensive effect with NSAIDs
  • Increased bleeding risk with warfarin
  • Interference with drug absorption due to gastric acid secretion inhibition
  • Effect of high-fat food on absorption

Contraindications

  • Hypersensitivity to tablet components
  • Asthma or allergic-type reactions to aspirin or NSAIDs
  • Use after coronary artery bypass graft (CABG) surgery

Side Effects

  • Decreased occurrence of gastric ulcers
  • Risk of arterial thrombotic events
  • Gastrointestinal adverse events
  • Oedema, hypertension, and cardiac failure
  • Gastrointestinal symptoms

Pregnancy & Lactation

  • Cautions during pregnancy and breastfeeding
  • Impaired female fertility with NSAID use

Precautions & Warnings

  • Avoid use with other NSAIDs
  • Minimize undesirable effects
  • Risk factors for gastrointestinal complications
  • Increased adverse reactions in older people
  • Gastrointestinal, cardiovascular, and renal effects
  • Special considerations for older people, gastrointestinal disease, and cardiovascular risk factors

Use in Special Populations

  • Dose adjustment for elderly patients
  • Not recommended for moderate to severe renal impairment
  • Close monitoring for hepatic insufficiency

Overdose Effects

  • Symptoms related to Naproxen and Esomeprazole overdose
  • Management for Naproxen and Esomeprazole overdose

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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