Nipotin 4000 IU (IV/SC Injection)
4000 IU pre-filled syringe: ৳ 1,900.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Erythropoietin alfa |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Treatment of anemia in Chronic Kidney Disease (CKD) patients on dialysis and not on dialysis
- Treatment of anemia in HIV-infected patients receiving Zidovudine
- Treatment of anemia due to the effects of myelosuppressive chemotherapy
- Reduction of allogeneic RBC transfusions in patients undergoing elective noncardiac nonvascular surgery
- Prevention of anemia of prematurity in infants with specific birth weight and gestational age
Description
- Recombinant human erythropoietin (EPO)
- Expressed in Chinese hamster ovary cells
- Has a 165 amino acid sequence identical to human urinary EPO
Dosage
- Evaluation of iron stores and nutritional factors before and during treatment
- Monitoring hemoglobin levels at least weekly for CKD patients
- Consideration of hemoglobin rate of rise, decline, and variability when adjusting therapy
- Specific starting dose and administration guidelines for CKD patients on dialysis and not on dialysis
- Starting dose and dose adjustment recommendations for Zidovudine-treated HIV-infected patients
- Initiation and dosing instructions for patients on cancer chemotherapy
Administration
- Instructions for preparation and administration
- Guidelines to not shake or use frozen Erythropoietin alfa
- Visual inspection for particulate matter and discoloration prior to administration
- Recommendation to protect syringe from light and discard unused portions
Interaction
- Potential potentiation by simultaneous administration of a haematinic agent such as ferrous sulphate
Contraindications
- Uncontrolled hypertension
- Serious allergic reactions to Erythropoietin alfa
- Patients who develop Pure Red Cell Aplasia (PRCA) following treatment with any erythropoietin
Side Effects
- List of adverse reactions observed in Nipotin treated patients in clinical studies
Pregnancy & Lactation
- Cautionary use in pregnancy and lactation due to limited studies
- Guidance on considering potential benefits and risks to the fetus and the nursing child
Overdose Effects
- Potential effects of Nipotin overdosage
- Management of hemoglobin levels above the desired level
- Cases of severe hypertension observed following overdosage with ESAs
Therapeutic Class
- Therapeutic class of Drugs for Haemolytic Hypoplastic & Renal Anemia
Storage Conditions
- Specific temperature range for storage
- Instruction to not freeze or shake
- Guidance to store in original package to protect from light