Nipotin 5000 IU (IV/SC Injection)

5000 IU pre-filled syringe: ৳ 2,150.00

Medicine Details

Category Details
Generic Erythropoietin alfa
Company Aristopharma ltd
Also available as
Nipotin 2000 iu injection Nipotin 3000 iu injection Nipotin 4000 iu injection Nipotin 10000 iu injection

Therapeutic Class

  • Drugs for Haemolytic Hypoplastic & Renal Anemia

Indications

  • Treatment of anemia in Chronic Kidney Disease (CKD) patients
  • Treatment of anemia in Zidovudine-treated HIV-infected patients
  • Treatment of anemia in patients undergoing myelosuppressive chemotherapy
  • Reduction of allogeneic RBC transfusions in patients undergoing elective, noncardiac, nonvascular surgery
  • Prevention of anemia of prematurity in infants with specific birth weight and gestational age

Description

  • Recombinant human erythropoietin (EPO)
  • Expressed in Chinese hamster ovary cells
  • Has a 165 amino acid sequence identical to that of human urinary EPO
  • Apparent molecular weight of about 30,400 daltons

Storage Conditions

  • Store at 2°C to 8°C
  • Do not freeze or shake
  • Store in original package to protect from light

Dosage

  • Evaluate iron status and maintain iron repletion before and during treatment
  • Monitor hemoglobin levels at least weekly until stable, then at least monthly
  • Consider initiating treatment based on specific hemoglobin levels
  • Do not increase the dose more frequently than once every 4 weeks
  • Adjust dose based on hemoglobin response

Administration

  • Do not shake or use if shaken or frozen
  • Protect syringe from light
  • Inspect visually for particulate matter and discoloration before administration
  • Discard unused portions

Interaction

  • Effect may be potentiated by simultaneous therapeutic administration of haematinic agents

Contraindications

  • Uncontrolled hypertension
  • Serious allergic reactions to Erythropoietin alfa
  • History of Pure Red Cell Aplasia (PRCA) following erythropoietin treatment

Side Effects

  • Adverse reactions in CKD patients, Zidovudine-treated HIV-infected Patients, Cancer Patients on Chemotherapy, Surgery Patients, and Premature infants

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Reproduction toxicology observed in animal studies
  • Use in pregnancy only if potential benefit outweighs potential risk to the fetus
  • Not recommended in pregnant or lactating surgical patients participating in autologous blood predonation program
  • Caution in nursing women with decision based on benefit of breast feeding and Erythropoietin alfa therapy

Overdose Effects

  • Nipotin overdosage may cause hemoglobin levels above desired level
  • Manage with discontinuation or reduction of dosage and/or phlebotomy
  • Severe hypertension observed following overdose with ESAs

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