Debolin 200000 IU/ml (Injectable Solution (Oral & IM))
1 ml ampoule: ৳ 120.00 (5's pack: ৳ 600.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Cholecalciferol vitamin d3 |
| Company | Chemist laboratories ltd |
| Also available as |
Indications
- Prevention of rickets
- Prevention of osteomalacia
- Prevention of osteoporosis
- Immunity boost
Pharmacology
- Active form: Calcitriol
- Vitamin D receptors (VDRs) binding
- Fat soluble with a half life of about 50 days
- Absorbed in the small intestine
- Metabolized to 25-hydroxy Vitamin D3 (Calcidiol)
- Second hydroxylation occurs in the kidney
- Non-metabolized Vitamin D3 stored in tissues
- Elimination via feces and urine
Dosage & Administration
- Multiple dosage forms: capsule, film-coated tablet, oroflash/chewable tablet, syrup, injection
- Different dosage regimens for adults and children
- Doses for treatment and prevention of deficiency
- Addition to specific therapy for osteoporosis
- Instructions on timing of intake with food
Interaction
- Drugs causing Vitamin D3 deficiencies
- Drugs increasing the need for Vitamin D3
Contraindications
- Contraindicated in diseases associated with hypercalcemia
- Contraindicated in known hypersensitivity
Side Effects
- Anorexia
- Lassitude
- Nausea & vomiting
- Diarrhea
- Constipation
- Weight loss
- Polyuria
- Sweating
- Headache
- Thirst
- Vertigo
- Raised concentrations of calcium and phosphate in plasma and urine
Pregnancy & Lactation
- Safe use of doses up to 4000 IU during pregnancy
- Recommended daily intake for pregnant women: 400 IU
- Excretion of Vitamin D3 and its metabolites in breast milk
- Considerations when prescribing additional vitamin D3 to a breast-fed child
Precautions & Warnings
- Plasma-calcium concentration monitoring
- Consultation before supplementing with Vitamin D3 in specific conditions
- Monitoring in renal impairment, and during pregnancy & lactation
Use in Special Populations
- Safety & efficacy in children under 12 years not established
Overdose Effects
- Hypervitaminosis D
Therapeutic Class
- Vitamin in bone formation
- Vitamin-D preparations
Storage Conditions
- Temperature below 30°C
- Protected from light & moisture
- Keep out of the reach of children