Osteo-D 200000 IU/ml (Injectable Solution (Oral & IM))

1 ml ampoule: ৳ 120.00

Medicine Details

Category Details
Generic Cholecalciferol vitamin d3
Company Incepta pharmaceuticals ltd
Also available as
Osteo d 200 iu pediatric drop Osteo d 1000 iu chewable tablet Osteo d 20000 iu capsule Osteo d 40000 iu capsule

Indications

  • Prevention of Vitamin D3 deficiency
  • Treatment of Vitamin D3 deficiency
  • Immunity boost up
  • Prevention of rickets
  • Prevention of osteomalacia
  • Prevention of osteoporosis
  • Prevention of pre-eclampsia during pregnancy
  • Prevention of pre-eclampsia during breast feeding
  • Essential nutrient for a growing infant
  • Essential for healthy bones and teeth

Pharmacology

  • Active form: Calcitriol
  • Binds to Vitamin D receptors (VDRs)
  • Fat-soluble with a half-life of about 50 days
  • Absorbed in the small intestine
  • Metabolized to 25-hydroxy Vitamin D3 (Calcidiol)
  • Metabolized to 1,25-dihydroxy Vitamin D3 (Calcitriol) in the kidney
  • Increases absorption of calcium
  • Stored in tissues such as fat and muscle
  • Eliminated via faeces and urine

Dosage & Administration

  • 40000 IU once weekly for 7 weeks for adults with Vitamin D3 deficiency
  • 1400-2000 IU/day for maintenance therapy in adults
  • 20000 IU every 4 weeks for prevention of Vitamin D3 deficiency in adults
  • 20000 IU once a month for addition to specific therapy for osteoporosis in adults
  • 20000 IU once every 2 weeks for 6 weeks for children with Vitamin D3 deficiency
  • 20000 IU every 6 weeks for prevention of Vitamin D3 deficiency in children
  • 1000 IU (1-2 tablets) daily for film-coated tablet for adults
  • 1000 IU to 2000 IU daily for oroflash or chewable tablets for adults
  • 400 IU/day (2 ml) for infants with risk of Cholecalciferol deficiency
  • 600 IU/day (3 ml) for children with risk of Cholecalciferol deficiency
  • 2000 IU/day (+50000 IU/week) for 6 weeks for infants with Cholecalciferol deficiency
  • 2000 IU/day for 6 weeks for children with Cholecalciferol deficiency
  • Various dosage options for injection in different age groups and conditions

Interaction

  • Magnesium containing Antacids
  • Digoxin
  • Thiazide Diuretics
  • Cholestyramine
  • Cholistipol
  • Phenytoin
  • Phenobarbital
  • Orlistat
  • Mineral Oil
  • Corticosteroids such as Prednisolone

Contraindications

  • Hypercalcaemia
  • Hypersensitivity to Vitamin D3 or similar medicines
  • Evidence of Vitamin D3 toxicity

Side Effects

  • Anorexia
  • Lassitude
  • Nausea & vomiting
  • Diarrhea
  • Constipation
  • Weight loss
  • Polyuria
  • Sweating
  • Headache
  • Thirst
  • Vertigo
  • Raised concentrations of calcium in plasma and urine
  • Raised concentrations of phosphate in plasma and urine

Pregnancy & Lactation

  • Safe use of doses up to 4000 IU during pregnancy
  • Excretion in breast milk
  • Recommended daily intake for pregnant women: 400 IU
  • Excretion in breast milk
  • No observed overdose effects in breast-fed infants

Precautions & Warnings

  • Monitoring plasma-calcium concentration in patients receiving high doses
  • Consultation required for patients using Digoxin and Thiazide Diuretics
  • Consultation required for patients with liver or kidney disease, primary hyperthyroidism, lymphoma, tuberculosis, and granulomatous disease

Use in Special Populations

  • Safety & efficacy not established in children under 12 years

Overdose Effects

  • Hypervitaminosis D

Therapeutic Class

  • Vitamin in bone formation
  • Vitamin-D preparations

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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