A-B1 100 mg (Tablet)

Indications

• Treatment of thiamine deficiency such as Beriberi and Wernick's encephalopathy
• Neuritis associated with pregnancy
• Pellagra

Pharmacology

• Coenzyme for decarboxylation of α-ketoglutaric acid
• Affects the peripheral nervous system, gastrointestinal tract, and cardiovascular system
• Necessary for optimal growth of infants and children
• Not stored in the body and regularly lost during deficiency
• Elevated requirements during pregnancy, carbohydrate rich diet, and alcoholism
• Effects of thiamine deficiency: fatigue, anorexia, gastrointestinal disturbance, tachycardia, irritability, neurological symptoms
• Well absorption from the gastrointestinal tract
• Rapid absorption from the upper small intestine
• Not stored in the body to a significant extent
• Plasma half life of 24 hours

Dosage & Administration

• Prophylaxis: 3 to 10 mg daily
• Mild chronic deficiency: 10 to 25 mg daily
• Severe deficiency: 200 to 300 mg daily

Interaction

• No hazardous drug interactions reported
• Acts synergistically with other B-complex group vitamins

Contraindications

• No absolute contraindication
• Risk of anaphylaxis increased by repeated parenteral administration
• Mild allergic phenomena may lead to anaphylactic shock
• Injection should not be given intravenously except in comatose patients

Side Effects

• No adverse effects when given orally
• Anaphylactic reactions with large intravenous doses in sensitive patients
• Risk of reactions increases with repeated parenteral administration
• Transient mild soreness at the site of intramuscular administration

Pregnancy & Lactation

• Safe for neonates, children, pregnant, lactating women, and elderly patients

Therapeutic Class

• Vitamin-B preparations

Storage Conditions

• Should be protected from light and moisture

Related Brands