Thiason 100 mg/ml (IM/IV Injection)
10 ml vial: ৳ 19.22
Medicine Details
| Category | Details |
|---|---|
| Generic | Thiamine hydrochloride |
| Company | Jayson pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of thiamine deficiency
- Beriberi
- Wernick's encephalopathy
- Neuritis associated with pregnancy
- Pellagra
- Prophylactic use for low dietary intake
- Prophylactic use for impaired gastrointestinal absorption of thiamine
- Prophylactic use for increased requirements like in pregnancy and carbohydrate-rich diet
Pharmacology
- Coenzyme for decarboxylation of α-ketoglutaric acid
- Affects peripheral nervous system
- Affects gastrointestinal tract
- Affects cardiovascular system
- Necessary for optimal growth of infants and children
- Not stored in the body
- Regularly lost from tissues during deficiency
- Required for normal health
- Rapid absorption from upper small intestine
- Widely distributed throughout the body
- Not stored in the body to any appreciable extent
- Plasma half-life of 24 hours
Dosage & Administration
- Prophylaxis: 3 to 10 mg daily
- Mild chronic deficiency: 10 to 25 mg daily
- Severe deficiency: 200 to 300 mg daily
Interaction
- Synergistic effects with other B-complex vitamins
- Reduced potential for adverse effects
Contraindications
- Risk of anaphylaxis with repeated parenteral administration
- Mild allergic phenomena as warning signs
- Avoid intravenous administration except in comatose patients
- No need for parenteral administration once deficiency is corrected
Side Effects
- No adverse effects when given orally
- Anaphylactic reactions with large intravenous doses
- Risk increases with repeated parenteral administration
- Transient mild soreness at intramuscular administration site
Pregnancy & Lactation
- Safe for neonates
- Safe for children
- Safe for pregnant women
- Safe for lactating women
- Safe for elderly patients
Therapeutic Class
- Vitamin-B preparations
Storage Conditions
- Protection from light
- Protection from moisture