Becosules (Capsule)

Indications

• Treatment of patients with deficiencies of vitamin B-complex and vitamin C
• Decreased intake due to restricted or unbalanced diet
• Reduced availability during treatment with antimicrobials
• Increased requirements due to fever and tissue wasting
• Micronutrient deficiencies during pregnancy or lactation

Composition

• Ascorbic Acid BP 175.0 mg
• Calcium D-Pantothenate BP 25.0 mg
• Cyanocobalamin BP 5 mcg
• Folic Acid BP 500 mcg
• Thiamine Mononitrate USP 50.0 mg
• Riboflavin BP 25.0 mg
• Pyridoxine Hydrochloride BP 10.0 mg
• Nicotinamide BP 100.0 mg

Pharmacology

• Vitamin B-Complex and Vitamin C as cofactors of various enzymes
• Thiamine acts as a cofactor in the decarboxylation of keto acids
• Riboflavin plays a vital role in cellular respiratory reactions
• Pyridoxine takes part in decarboxylation and interconversion of amino acids
• Vitamin B12 required for synthesis of DNA and maturation of RBCs
• Nicotinamide plays a vital role in cellular respiration
• Calcium Pantothenate functions as a cofactor for enzymes involved in transfer of acetyl groups
• Folic acid takes part in reactions involved in the synthesis of nucleotides and maturation of RBCs
• Ascorbic acid takes part in biochemical reactions involving oxidation
• Adequate supply of water-soluble vitamins is required for optimum function of cells and tissues

Dosage & Administration

• One capsule daily or as advised by the physician

Interaction

• Folic acid may lower the serum concentration of phenytoin
• Pyridoxine can reduce the effect of levodopa

Contraindications

• Hypersensitivity to any of the ingredients of this preparation

Side Effects

• Allergic reactions may occur in patients hypersensitive to any component in the preparation
• Rare reports of anaphylactoid reactions following repeated injection of preparations containing thiamine
• Flushing, itching, or burning of the skin may occur in patients susceptible to the effects of nicotinamide

Pregnancy & Lactation

• Published reports on safe administration of water-soluble vitamins in pregnancy

Precautions & Warnings

• Specific therapy for the primary illness in patients with deficiency or increased requirement of Vitamin B-complex and Vitamin C
• Treatment should be continued only until the deficiency is corrected or the need for supplementation exists
• Pyridoxine may reduce therapeutic effects of levodopa in Parkinson's disease
• Riboflavin may color the urine yellow
• Presence of ascorbic acid may give a false positive result for sugar by Benedict's test

Therapeutic Class

• Specific combined vitamin preparations

Storage Conditions

• Store in a cool and dry place, away from light and children

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