Prokind 15 mg (Tablet)

Indications

• Adjunctive therapy in the treatment of peptic ulcer (gastric and duodenal)
• Relief of the symptoms of gastritis (stomach upset, gastrointestinal bleeding, blood in vomit, blood in stool, persistent pain)
• Symptomatic treatment of the diarrhoea related irritable bowel syndrome (irritable colon, spastic colon, acute enterocolitis, functional Gl disorders etc)
• Urinary incontinence
• Control of salivation and enuresis
• Improves lactose intolerance
• Prevents excessive sweating (Hyperhidrosis)

Pharmacology

• Specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites
• Direct effect upon smooth muscle (musculotropic)
• Reduces the effect of acetylcholine on smooth muscle
• Inhibits gastrointestinal motility
• Decreases gastric acid secretion
• Controls excessive pharyngeal, tracheal, and bronchial secretions
• Reduces pancreatic juice, sweat, and saliva

Dosage & Administration

• Usual initial adult dose of 75 mg daily
• One tablet 30 minutes before each meal (15 mg three times daily)
• Two tablets at bedtime
• Maximum daily dosage should not exceed 120 mg

Interaction

• Antacids or Absorbent Antidiarrhoeals may reduce absorption of Prokind
• Anticholinergics may delay absorption of other medication
• Significant drug interaction with digoxin, haloperidol, corticosteroides, ketoconazole, levodopa, opioid analgesics, phenothiazines, urinary alkalizers

Contraindications

• Hypersensitivity to Propantheline bromide or other anticholinergic agents
• Glaucoma
• Obstructive disease of the gastrointestinal tract (pyloroduodenal stenosis, paralytic ileus etc.)
• Obstructive uropathy (e.g. prostatic hypertrophy) intestinal atony of elderly
• Myasthenia gravis

Side Effects

• Variable degrees of dry mouth
• Dry skin
• Mydriasis
• Urinary retention
• Nausea
• Vomiting
• Constipation
• Headache
• Nervousness
• Mental confusion

Pregnancy & Lactation

• Pregnancy category C
• Caution advised for pregnant and nursing women
• Suppression of lactation may occur

Precautions & Warnings

• Caution in the elderly
• Caution in patients with autonomic neuropathy, hepatic or renal disease, hyperthyroidism, coronary heart disease, congestive heart failure, cardiac tachyarrhythmias, hypertension

Overdose Effects

• Intensification of usual side effects
• CNS disturbances
• Circulatory changes
• Respiratory failure
• Paralysis

Therapeutic Class

• Anticholinergics (antimuscarinics)/ Anti-spasmodics

Storage Conditions

• Do not store above 30°C
• Keep away from light
• Keep out of the reach of children

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