Antrenex 5 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Oxyphenonium bromide |
| Company | Opsonin pharma ltd |
Indications
- Gastro-intestinal spasm
- Hypermotility
- Cardiospasm
- Esophagospasm
- Gastroduodenitis
- Spastic constipation
- Pylorospasm
- Peptic ulcer
- Spasm associated with carcinoma
- Pain and spasm of the biliary tract
- Pain and spasm of the urinary tract
Pharmacology
Anticholinergic drug that reduces the effect of acetylcholine, has a direct relaxing effect on smooth muscle, inhibits gastrointestinal propulsive motility, decreases gastric acid secretion, controls excessive pharyngeal, tracheal and bronchial secretions
Dosage & Administration
Average adult dosage is 10 mg (2 tablets) 4 times daily for several days. Dosage may be reduced depending on patient's response or as directed by the physician
Interaction
Reduced gastric motility interferes with absorption of other drugs. Effects potentiated by other antimuscarinics including amantadine, some antihistamines, phenothiazines and TCA
Contraindications
- Glaucoma
- Obstructive uropathy
- Obstructive disease of the gastrointestinal tract
- Intestinal atony of the elderly or debilitated patient
- Unstable cardiovascular status in acute hemorrhage
- Severe ulcerative colitis
- Toxic megacolon
- Complicating ulcerative colitis
- Myasthenia gravis
- Hypersensitivity
Side Effects
- Dryness of mouth
- Headache
- Palpitations
Pregnancy & Lactation
Potential benefit justifies potential risk to the foetus
Precautions & Warnings
- Children
- Elderly
- Benign prostatic hyperplasia
- Acute MI, cardiac failure, hypertension, thyrotoxicosis
- Pregnancy and lactation
- Fever
- Angle-closure glaucoma
Overdose Effects
Treatment is the same as for atropine overdosage
Therapeutic Class
Anticholinergics (antimuscarinics)/ Anti-spasmodics
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children