Amisol 5% (IV Infusion)

500 ml bottle: ৳ 450.00

Medicine Details

Title and Category

  • Amino Acid IV Solution
  • Parenteral Nutritional Preparations

Indications

  • Source of amino acids for protein synthesis
  • Suitable for patients with basal amino acid requirements
  • Faster recovery in surgery, burns, renal insufficiency, hepatic insufficiency, and effective management of cancer

Composition

  • Contains essential amino acids like L-Isoleucine, L-Leucine, L-Lysine Hydrochloride, L-Methionine, L-Phenylalanine, L-Threonine, L-Tryptophan, L-Valine, L-Histidine, L-Tyrosine
  • Non-essential amino acids like L-Arginine, L-Aspartic Acid, L-Glutamic Acid, L-Alanine, L-Cystine, Glycine, L-Proline, L-Serine
  • Contains D-Sorbitol, Sodium, Potassium, Magnesium, Chloride, Acetate
  • Total Nitrogen Content: 7.25 gm/L
  • Total Energy Content: 1551 kj/L (371.14 Kcal/L)

Pharmacology

  • Sterile aqueous solution of crystalline amino acid and D-Sorbitol with electrolytes
  • Contains essential and non-essential amino acids required for protein synthesis
  • Clear, colorless to pale yellow colored solution with pH range of 5.0 to 7.0

Dosage and Administration

  • Dosing based on the patient's nutritional state and metabolic stress level
  • Dosage range varies from 0.10-0.25 g nitrogen/kg/day
  • Dosage in obese patients based on estimated ideal weight
  • In children and infants, recommended infusion rate is 28-35 ml/kg body weight per day

Interaction

  • No expected pharmacological effects or interactions at recommended dosage

Contraindications

  • Contraindicated in patients with inborn errors of amino acids metabolism, severe liver dysfunction, severe uremia when dialysis facilities are not available
  • Contraindicated in patients with hyperosmolar nonketotic diabetic coma

Side Effects

  • Rarely nausea, vomiting, flushing, sweating observed
  • Transient increase in liver test during intravenous nutrition reported
  • Hypersensitivity reactions reported
  • Thrombophlebitis may occur when peripheral veins are used

Pregnancy and Lactation

  • Successful and safe administration during pregnancy reported
  • No animal reproduction studies carried out

Precautions and Warnings

  • Increased urinary excretion of trace elements copper and zinc during IV infusion
  • Hyperphenylalaninemia may occur in severely ill, premature infants
  • Caution in patients with diabetes mellitus, severe heart failure, or renal function issues
  • Monitoring of serum potassium and blood glucose recommended

Overdose Effects

  • Augmented risk for nausea, vomiting, sweating
  • Thrombophlebitis and osmotic diuresis with dehydration may occur
  • Risk of symptoms related to hyperglycemia
  • In case of overdose symptoms, slow down or discontinue the infusion

Storage Conditions

  • Protect from light
  • Store between 15°C to 25°C temperature
  • Avoid freezing
  • Keep out of reach of children

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